Development of Tube Radial Distribution Chromatography Based on Phase-Separation Multiphase Flow Created <i>via</i> Pressure Loss

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  • WADA Susumu
    Applied Chemistry, Graduate School of Science and Engineering, Doshisha University
  • TSUKAGOSHI Kazuhiko
    Applied Chemistry, Graduate School of Science and Engineering, Doshisha University
  • TSUCHIYA Katsumi
    Applied Chemistry, Graduate School of Science and Engineering, Doshisha University
  • HIROTA Ken
    Applied Chemistry, Graduate School of Science and Engineering, Doshisha University
  • YAMASHITA Kenichi
    Advanced Manufacturing Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)
  • MURATA Masaharu
    Department of Advanced Medical Initiatives, Faculty of Medical Sciences, Kyushu University

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  • Development of Tube Radial Distribution Chromatography Based on Phase-Separation Multiphase Flow Created via Pressure Loss

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Abstract

<p>A tube radial distribution chromatography (TRDC) method based on phase-separated multiphase flow created through phase transformation via temperature change has been developed. These systems typically required a temperature-controlling device containing a water bath and a stirrer. Herein, we proposed a novel TRDC system without a cooling device, where the phase transformation was achieved via pressure loss in a capillary tube of 50 μm inner diameter and 550 cm length. Model analytes were successfully separated with the developed TRDC system, which provided a simplified platform and helped to clarify the operating principle of TRDC based on phase transformation in a capillary tube.</p>

Journal

  • Analytical Sciences

    Analytical Sciences 35 (7), 803-806, 2019-07-10

    The Japan Society for Analytical Chemistry

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