Periostin as a predictor of prognosis in chronic bird-related hypersensitivity pneumonitis

• Nukui Yoshihisa

  Department of Respiratory Medicine, Tokyo Medical and Dental University

• Miyazaki Yasunari

  Department of Respiratory Medicine, Tokyo Medical and Dental University

• Masuo Masahiro

  Department of Respiratory Medicine, Tokyo Medical and Dental University

• Okamoto Tsukasa

  Department of Respiratory Medicine, Tokyo Medical and Dental University

• Furusawa Haruhiko

  Department of Respiratory Medicine, Tokyo Medical and Dental University

• Tateishi Tomoya

  Department of Respiratory Medicine, Tokyo Medical and Dental University

• Kishino Mitsuhiro

  Department of Diagnostic Radiology, Tokyo Medical and Dental University

• Tateishi Ukihide

  Department of Diagnostic Radiology, Tokyo Medical and Dental University

• Ono Junya

  Shino-Test Corporation

• Ohta Shoichiro

  Department of Medical Technology and Sciences, School of Health Sciences at Fukuoka, International University of Health and Welfare

• Izuhara Kenji

  Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School

• Inase Naohiko

  Department of Respiratory Medicine, Tokyo Medical and Dental University

Abstract

Background: Periostin is an established biomarker of Th2 immune response and fibrogenesis. Recent research has indicated that periostin plays an important role in the pathogenesis of idiopathic interstitial pneumonias. To clarify the relationship between periostin and pathogenesis in chronic bird-related hypersensitivity pneumonitis (HP) and to reveal the usefulness of serum periostin levels in diagnosing and managing chronic bird-related HP. Methods: We measured serum periostin in 63 patients with chronic bird-related HP, 13 patients with idiopathic pulmonary fibrosis, and 113 healthy volunteers. We investigated the relationship between serum periostin and clinical parameters, and evaluated if the baseline serum periostin could predict the prognosis. Results: Serum periostin was significantly higher in patients with chronic bird-related HP compared to the healthy volunteers. In chronic bird-related HP, serum periostin had significant positive correlations with serum KL-6 levels, the CD4/CD8 ratio in bronchoalveolar lavage fluid, and fibrosis score on HRCT, and a significant negative correlation with the diffusing capacity of the lungs for carbon monoxide. Chronic bird-related HP patients with serum periostin levels exceeding ≥92.5 ng/mL and ≥89.5 ng/mL had a significantly worse prognosis and significantly higher frequency of acute exacerbation, respectively. Higher serum periostin (92.5 ng/mL or higher; binary response for serum periostin) was an independent prognostic factor in multivariate analysis. Conclusions: Serum periostin may reflect the extent of lung fibrosis and play an important role in pathogenesis of chronic bird-related HP. Elevated serum periostin could be a predictor of prognosis in patients with chronic bird-related HP.

Journal

• Allergology International

  Allergology International 68 (3), 363-369, 2019

  Japanese Society of Allergology

Keywords

• Biomarker
• Chronic hypersensitivity pneumonitis
• High-resolution computed tomography
• Lung fibrosis
• Periostin

Details

• CRID: 1390564238106494336
• NII Article ID: 130007678459
• DOI: 10.1016/j.alit.2019.02.007
• ISSN: 14401592
• ISSN: 13238930
• Web Site: https://api.elsevier.com/content/article/PII:S1323893019300206?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S1323893019300206?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2020222176
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed