Usefulness of Ustekinumab for Treating a Case of Myelodysplastic Syndrome-associated Inflammatory Bowel Disease
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- Kono Masashi
- Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan
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- Sakurai Toshiharu
- Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan
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- Okamoto Kazuki
- Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan
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- Nagai Tomoyuki
- Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan
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- Komeda Yoriaki
- Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan
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- Kashida Hiroshi
- Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan
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- Minaga Kosuke
- Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan
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- Kamata Ken
- Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan
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- Takenaka Mamoru
- Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan
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- Hagiwara Satoru
- Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan
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- Watanabe Tomohiro
- Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan
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- Nishida Naoshi
- Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan
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- Enoki Eisuke
- Department of Pathology, Kindai University Faculty of Medicine, Japan
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- Inoue Hiroaki
- Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, Japan
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- Matsumura Itaru
- Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, Japan
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- Kudo Masatoshi
- Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan
Abstract
<p>Autoimmune diseases including inflammatory bowel disease (IBD) occur in association with myelodysplastic syndrome (MDS). MDS-associated IBD frequently demonstrates a complicated course. We herein report the first case with MDS-associated IBD that was successfully treated with ustekinumab (UST), an anti-interleukin (IL) 12/23p40 monoclonal antibody. A 63-year-old man with a 7-year history of MDS was referred for examination of diarrhea, abdominal pain and fever. A blood examination revealed a marked elevation of C-reactive protein. Colonoscopy showed multiple ulcers in the terminal ileum. He was resistant to anti-tumor necrosis factor (TNF)-α antibody and azacitidine. Subsequently, UST treatment reduced colonic IL-17 and IL-6 expression and the patient currently maintains a state of remission. </p>
Journal
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- Internal Medicine
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Internal Medicine 58 (14), 2029-2033, 2019-07-15
The Japanese Society of Internal Medicine