Acute swimming exercise, but not exposure to moderate hypoxic conditions reduces circulating selenoprotein P levels in short-term, high-fat diet-fed rats

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  • Dobashi Shohei
    Integrated Graduate School Department of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi
  • Nakamura Arisa
    Faculty of Education and Human Sciences, University of Yamanashi
  • Saito Kyohei
    Graduate School Department of Education, University of Yamanashi
  • Ando Daisuke
    Graduate School Department of Interdisciplinary Research, University of Yamanashi
  • Koyama Katsuhiro
    Graduate School Department of Interdisciplinary Research, University of Yamanashi

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<p>The purpose of this study was to investigate the impact of acute exercise and hypoxic exposure on the level of circulating selenoprotein P (SeP), which is known to cause insulin and exercise resistance, and expression of the muscle peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) gene in pre-diabetes rat models. Fifteen week old male Wistar rats (n = 20) were fed with a high-fat diet and water ad libitum for 3 weeks. After the acclimation period, they were assigned to sedentary or exercise groups under normoxic (20.9% O2) and hypoxic (14.5% O2) conditions. Each of the exercise groups (NE and HE) was administered two 30-min no-load swimming exercises with an interval of 5-min rest. The serum, the liver, and the triceps muscle were obtained 3 h after the exercises. Hypoxic exposure did not affect hepatic SeP mRNA, serum SeP protein, and muscle PGC-1α mRNA expression. In contrast, acute swimming exercise reduced circulating SeP concentration and increased PGC-1α mRNA expression in triceps muscle. In conclusion, acute swimming exercise rather than moderate hypoxic exposure might improve insulin and exercise resistance in pre-diabetes conditions for type 2 diabetes.</p>

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