Histopathological Features of Gamma-delta T-cell Lymphoma in Two Cows

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  • 牛におけるγδT細胞性リンパ腫2例の病理学的特徴
  • 獣医公衆衛生・野生動物・環境保全関連部門 牛におけるγδT細胞性リンパ腫2例の病理学的特徴
  • ジュウイ コウシュウ エイセイ ・ ヤセイ ドウブツ ・ カンキョウ ホゼン カンレン ブモン ウシ ニ オケル gdTサイボウセイ リンパシュ 2レイ ノ ビョウリガクテキ トクチョウ

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Abstract

<p>The histopathological and immunohistochemical features of lymphoma in two Holstein cows were studied. Histologically, both cases received a diagnosis of peripheral gamma-delta T-cell lymphoma, based on positive results for CD3, CD5, and WC1, and negative results for terminal deoxynucleotidyl transferase (TdT). In case one, the neoplastic cells had round to oval nuclei, most of which contained cytoplasmic eosinophilic granules, and a diagnosis of gamma-delta T-cell lymphoma, hypergranular variant was made. In contrast, in case two, the neoplastic cells showing variation in cell size and marked nuclear irregularity (convolution) were cytologically distinct from those in previously reported histological subtypes of gamma-delta T-cell lymphoma, and a diagnosis of pleomorphic gamma-delta T-cell lymphoma was made. Because this lymphoma is relatively difficult to distinguish cytologically from pleomorphic B cell lymphoma, immunohistochemistry is required for differential diagnosis.</p>

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