A case of epithelial-myoepithelial carcinoma arising in the hard palate

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  • OGANE Satoru
    Department of Oral and Maxillofacial Surgery, Tokyo Dental College Oral Cancer Center, Tokyo Dental College
  • SUZUKI Eiko
    Department of Oral Pathological Science and Surgery, Tokyo Dental College
  • ONDA Takeshi
    Department of Oral and Maxillofacial Surgery, Tokyo Dental College
  • NOMURA Takeshi
    Oral Cancer Center, Tokyo Dental College Department of Oral Medicine, Oral and Maxillofacial Surgery, Tokyo Dental
  • KATAKURA Akira
    Oral Cancer Center, Tokyo Dental College Department of Oral Pathological Science and Surgery, Tokyo Dental College
  • SHIBAHARA Takahiko
    Department of Oral and Maxillofacial Surgery, Tokyo Dental College Oral Cancer Center, Tokyo Dental College

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Other Title
  • 硬口蓋に発生した上皮筋上皮癌の1例
  • コウコウガイ ニ ハッセイ シタ ジョウヒキン ジョウヒガン ノ 1レイ

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Abstract

<p>Epithelial-myoepithelial carcinoma (EMC) is a rare low-grade malignant salivary gland neoplasm that accounts for less than 1% of all salivary gland neoplasms and most commonly occurs in the parotid gland. We report a case of primary epithelial-myoepithelial carcinoma of the left hard palate. The patient was a 76-year-old woman who was referred to our hospital because of a painless mass in the left hard palate. T2-weighted magnetic resonance (MR) imaging revealed a clearly demarcated, somewhat heterogeneous, hyperintense tumor with partially irregular margins. Because the preoperative histological examination revealed that the salivary gland tumor might be malignant, surgical resection of the malignant palatal tumor was performed with the patient under general anesthesia. In the resected tissue, the tumor was composed of multilobular proliferations of biphasic tubules of inner eosinophilic cells and outer clear cells. Immunohistochemical examination revealed that the outer layer consisted of clear myoepithelial cells positive for S-100 protein (S-100), vimentin, α-smooth muscle actin (α-SMA), and glial fibrillary acidic protein (GFAP), and the inner layer consisted of duct-forming epithelial cells positive for pan-cytokeratin (AE1/AE3). On the basis of these results, EMC was diagnosed. No signs of recurrence or distant metastasis have been seen as of 4 years postoperatively, and the progress of the patient has been satisfactory.</p>

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