Additive effects of Kothala himbutu (<i>Salacia reticulata</i>) extract and a lactic acid bacterium (<i>Enterococcus faecalis</i> YM0831) for suppression of sucrose-induced hyperglycemia in an <i>in vivo </i>silkworm evaluation system
-
- Ishii Masaki
- Genome Pharmaceuticals Institute Co., Ltd. Molecular Cell Biology Laboratory, Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University
-
- Matsumoto Yasuhiko
- Teikyo University Institute of Medical Mycology Department of Microbiology, Meiji Pharmaceutical University
-
- Katada Toshiaki
- Molecular Cell Biology Laboratory, Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University
-
- Sekimizu Kazuhisa
- Genome Pharmaceuticals Institute Co., Ltd. Teikyo University Institute of Medical Mycology
この論文をさがす
抄録
<p>Using a silkworm evaluation system, we previously evaluated various substances that suppress postprandial hyperglycemia. Enterococcus faecalis YM0831, a lactic acid bacterium that inhibits glucose uptake by the human intestinal Caco-2 cell line, exhibited hyperglycemia-suppressing effects in the silkworm system. In the present study, we found that Kothala himbutu (Salacia reticulata) extract, a traditional medicine containing α-glucosidase inhibitors, suppressed sucrose-induced hyperglycemia in the silkworm system. Moreover, combined oral administration of lactic acid bacteria YM0831 with Kothala himbutu extract had stronger suppressive effects on sucrose-induced hyperglycemia than single administration of either component. These findings suggest that the silkworm system provides a simple way to evaluate the effects of supplements on the suppression of blood glucose level induced by sucrose ingestion.</p>
収録刊行物
-
- Drug Discoveries & Therapeutics
-
Drug Discoveries & Therapeutics 13 (3), 133-136, 2019-06-30
特定非営利活動法人 バイオ＆ソーシャル・サイエンス推進国際研究交流会