LATE BREAKING COHORT STUDY (JCS 2019) : Contemporary Antiplatelet Therapy and Clinical Outcomes of Japanese Patients With Acute Myocardial Infarction : Results From the Prospective Japan Acute Myocardial Infarction Registry (JAMIR)
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- Yasuda Satoshi
- Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
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- Honda Satoshi
- Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
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- Takegami Misa
- Department of Preventive Medicine and Epidemiologic Informatics, National Cerebral and Cardiovascular Center
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- Nishihira Kensaku
- Department of Cardiovascular Medicine, Miyazaki Medical Association Hospital
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- Kojima Sunao
- Department of General Internal Medicine 3, Kawasaki Medical School
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- Asaumi Yasuhide
- Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
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- Suzuki Makoto
- Department of Cardiology, Sakakibara Heart Institute
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- Kosuge Masami
- Department of Cardiovascular Medicine, Yokohama City University Medical Center
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- Takahashi Jun
- Department of Cardiovascular Medicine, Tohoku University
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- Sakata Yasuhiko
- Department of Cardiovascular Medicine, Tohoku University
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- Takayama Morimasa
- Department of Cardiology, Sakakibara Heart Institute
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- Sumiyoshi Tetsuya
- Department of Cardiology, Sakakibara Heart Institute
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- Ogawa Hisao
- Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
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- Kimura Kazuo
- Department of Cardiovascular Medicine, Yokohama City University Medical Center
書誌事項
- タイトル別名
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- Contemporary Antiplatelet Therapy and Clinical Outcomes of Japanese Patients With Acute Myocardial Infarction ― Results From the Prospective Japan Acute Myocardial Infarction Registry (JAMIR) ―
- Contemporary antiplatelet therapy and clinical outcomes of Japanese patients with acute myocardial infarction — results from the prospective Japan Acute Myocardial Infarction Registry (JAMIR)
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抄録
<p>Background:Antiplatelet therapy is the corner stone of treatment following acute myocardial infarction (AMI). Prasugrel, a new and potent antiplatelet agent, was recently introduced to clinical practice. We compared the clinical outcomes of patients with AMI treated with prasugrel with those treated with clopidogrel in real-world clinical practice in Japan.</p><p>Methods and Results:The Japan AMI Registry (JAMIR) is a multicenter, nationwide, prospective registry enrolling patients with AMI from 50 institutes. Between December 2015 and May 2017, a total of 3,411 patients were enrolled. Among them, 3,069 patients were treated with either prasugrel (n=2,607) or clopidogrel (n=462) during hospitalization. Median follow-up period was 12 months. Prasugrel-treated patients were predominantly male, younger, more often showed ST-elevation AMI, and had fewer comorbidities. After adjustment using inverse probability of treatment weighting, the primary endpoint, defined as a composite of cardiovascular death, non-fatal MI and non-fatal stroke, was comparable between the prasugrel and clopidogrel groups (adjusted hazard ratio [HR] 1.07, 95% confidence interval [CI] 0.67–1.72), whereas the risk of major bleeding (BARC type 3 or 5 bleeding) was significantly lower in the prasugrel group (adjusted HR 0.62, 95% CI 0.39–0.99).</p><p>Conclusions:The present real-world database of the JAMIR demonstrated that the potent P2Y12-inhibitor prasugrel showed comparable rates of 1-year ischemic events to clopidogrel, but the risk of bleeding was lower with prasugrel than with clopidogrel.</p>
収録刊行物
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- Circulation Journal
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Circulation Journal 83 (8), 1633-1643, 2019-07-25
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390282763131576064
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- NII論文ID
- 130007683013
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL書誌ID
- 029816559
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- PubMed
- 31204353
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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