Mechanisms of <i>O</i>-Mannosyl Glycan Biosynthesis in Mammals

• Manya Hiroshi

  Molecular Glycobiology, Research Team for Mechanism of Aging, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology

説明

We previously reported that a defect in O-mannosyl glycan is the primary cause of a group of congenital muscular dystrophies. Based on our pioneering findings, numerous studies have been performed and revealed various structures of O-mannosyl glycans. However, the glycan structure associated with muscular dystrophies remained unclear for a long time. Recently, we described the complete structure of an O-mannosyl glycan containing ribitol-phosphate (RboP), which had not previously been identified as a glycan component in mammals. In addition, its unique biosynthetic pathway was elucidated by identifying the functions of the gene products associated with muscular dystrophies. Here, we review recent findings regarding the mechanisms of O-mannosyl glycan biosynthesis in mammals.

収録刊行物

• Ｔｒｅｎｄｓ　ｉｎ　Ｇｌｙｃｏｓｃｉｅｎｃｅ　ａｎｄ　Ｇｌｙｃｏｔｅｃｈｎｏｌｏｇｙ

  Ｔｒｅｎｄｓ　ｉｎ　Ｇｌｙｃｏｓｃｉｅｎｃｅ　ａｎｄ　Ｇｌｙｃｏｔｅｃｈｎｏｌｏｇｙ 31 (181), SE63-SE64, 2019-07-25

  FCCA(Forum: Carbohydrates Coming of Age)

キーワード

• <i>O</i>-mannosyl glycan
• muscular dystrophy
• α-dystroglycan
• ribitol-phosphate
• fukutin
• FKRP
• ISPD
• RXYLT1
• POMGNT1

詳細情報

• CRID: 1390282763130833792
• NII論文ID: 130007683661
• DOI: 10.4052/tigg.1930.2se
• ISSN: 18832113
• ISSN: 09157352
• Web Site: https://www.jstage.jst.go.jp/article/tigg/31/181/31_1930.2SE/_pdf
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可