Single nucleotide polymorphism as an indicator of short stature and dyslipidemia in community-dwelling elderly Japanese subjects

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  • Tezuka Kazuhide
    Department of Cardiovascular Disease Prevention, Osaka Center for Cancer and Cardiovascular Disease Prevention
  • Shimizu Yuji
    Department of Cardiovascular Disease Prevention, Osaka Center for Cancer and Cardiovascular Disease Prevention Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science
  • Noguchi Yuko
    Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science
  • Sato Shimpei
    Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science
  • Koyamatsu Jun
    Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Science
  • Yamanashi Hirotomo
    Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Science
  • Nagayoshi Mako
    Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science
  • Kawashiri Shin-ya
    Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science
  • Nagata Yasuhiro
    Center for Comprehensive Community Care Education, Nagasaki University Graduate School of Biomedical Sciences
  • Maeda Takahiro
    Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Science

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Abstract

Aims: We previously reported an inverse association between adult height and dyslipidemia in subjects with low, but not high, body mass index (BMI) by elucidating genetic influences. However, the genetic factors that are associated with short stature and dyslipidemia in subjects with a low BMI are unknown. Methods: We conducted a cross-sectional study of 877 elderly Japanese subjects aged ≥60 years who underwent a national health check-up in 2014 and 2015. We focused on single nucleotide polymorphism (SNP) rs3782886, since this variant was reported to be associated with metabolic syndrome. Short stature was defined as the lowest 20% of the height distribution (‹157.8cm for men and ‹145.0cm for women), and dyslipidemia was defined by the Japan Atherosclerosis Society (JAS) guidelines as follows: triglycerides (TG) ≥150mg/dL and/or low density lipoprotein-cholesterol (LDL) ≥140mg/dL, and/or high density lipoproteincholesterol (HDL) ‹40mg/dL, and/or lipid lowering medication use. Results: Of the study population, 62.3% were major homo, 33.0% were hetero and 4.8% minor homo. With non-minor homo (major homo and hetero) as reference groups, minor homo was significantly positively associated with short stature independent of known cardiovascular risk factors. The multivariable odds ratio (OR) and 95% confidence interval (CI) of short stature for minor homo was 2.23 (1.07, 4.67). Minor homo also showed a significant positive association with dyslipidemia in subjects with a BMI‹23kg/m2, 3.20 (1.08, 9.51), but not in those with a BMI ≥23kg/m2 ,0.77 (0.32, 1.89). Conclusion: SNP rs3782886 is associated with short stature and dyslipidemia in elderly Japanese subjects with a BMI<23kg/m2.

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