Association of Uric Acid with Incident Metabolic Syndrome in a Japanese General Population
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- Sumiyoshi Hisako
- Clinical Investigation and Research Unit, Gunma University Hospital
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- Ohyama Yoshiaki
- Clinical Investigation and Research Unit, Gunma University Hospital Department of Cardiology, Gunma University
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- Imai Kunihiko
- Department of Internal Medicine, Gunma Chuo Hospital
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- Kurabayashi Masahiko
- Department of Cardiology, Gunma University
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- Saito Yuichiro
- System Integration Center, Gunma University Hospital
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- Nakamura Tetsuya
- Clinical Investigation and Research Unit, Gunma University Hospital Department of Cardiology, Gunma University
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抄録
<p>Uric acid is associated with cardiovascular disease (CVD) and its risk factors. Here, we examined the association between the serum uric acid level and incident metabolic syndrome in a Japanese general population. This retrospective, observational study was based on data obtained from an annual health checkup program in Gunma Prefecture, Japan. We evaluated 14,793 participants who did not use antihypertensive or antidiabetic medications and did not present with CVD or metabolic syndrome at the study baseline in 2009. Metabolic syndrome was defined as per the Japanese diagnostic criteria. A discrete proportional hazards regression model was used to evaluate the association between the serum uric acid level at baseline and the incident metabolic syndrome through 2012 and was adjusted for age, gender, waist circumference, systolic and diastolic blood pressure, fasting blood glucose, high-density lipoprotein cholesterol, and triglyceride. At baseline, the average age of the participants was 48.9 years, who were comprised of 40% women. The mean serum uric acid level at baseline was 5.3 ± 1.4 mg/dL. During the three-year follow-up, 7% of the cohort (n = 1,031) developed metabolic syndrome. The uric acid level was strongly associated with incident metabolic syndrome in the multivariable model (adjusted hazard ratio: 1.10; 95% confidence interval, 1.04-1.17; P < 0.01 per 1 mg/dL increase for uric acid). Higher uric acid levels were independently associated with a greater risk of incident metabolic syndrome in a Japanese general population.</p>
収録刊行物
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- International Heart Journal
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International Heart Journal 60 (4), 830-835, 2019-07-30
一般社団法人 インターナショナル・ハート・ジャーナル刊行会