Development of phthalocyanine-based fluorescence probes for detecting ascorbic acid

• YOKOI Takanori

  東京大学生産技術研究所　物質・環境系部門

• ISHII Kazuyuki

  東京大学生産技術研究所　物質・環境系部門

Bibliographic Information

Other Title

• フタロシアニンを用いたビタミンC検出用蛍光プローブの開発
• フタロシアニン オ モチイタ ビタミン C ケンシュツヨウ ケイコウ プローブ ノ カイハツ

Abstract

Ascorbic acid （Vitamin C） has been tested in the clinic against various forms of cancers, with some success. However, in vivo tracing of intravenously injected ascorbic acid has not been achieved. We have developed phthalocyaninatosilicon （SiPc） covalently linked to two tetramethyl-1-piperidinyloxyl （TEMPO） radicals as fluorescence probes for detecting ascorbic acid. These SiPc-based fluorescence probes were encapsulated into liposome or dimeric bovine serum albumin （BSA） in order to apply them to biological systems. Based on these encapsulations, we successfully imaged ascorbic acid administered to cancer cells or mice, for the first time. These results provide opportunities to advance the use of ascorbic acid as cancer therapy.

Journal

• SEISAN KENKYU

  SEISAN KENKYU 71 (4), 799-804, 2019-07-01

  Institute of Industrial Science The University of Tokyo

Details

• CRID: 1390282763131742208
• NII Article ID: 130007685295
• NII Book ID: AN00127075
• DOI: 10.11188/seisankenkyu.71.799
• ISSN: 18812058
• ISSN: 0037105X
• NDL BIB ID: 029934036
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I029934036
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed