Antimicrobial and antibiofilm efficacy of a copper/calcium hydroxide-based endodontic paste against <i>Staphylococcus aureus</i>, <i>Pseudomonas aeruginosa</i> and <i>Candida albicans </i>
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- METO Aida
- School of Doctorate in Clinical and Experimental Medicine, University of Modena and Reggio Emilia
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- COLOMBARI Bruna
- Department of Surgical, Medical, Dental and Morphological Sciences with interest in Transplant, Oncological and Regenerative Medicine; University of Modena and Reggio Emilia
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- SALA Arianna
- Department of Surgical, Medical, Dental and Morphological Sciences with interest in Transplant, Oncological and Regenerative Medicine; University of Modena and Reggio Emilia
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- PERICOLINI Eva
- Department of Surgical, Medical, Dental and Morphological Sciences with interest in Transplant, Oncological and Regenerative Medicine; University of Modena and Reggio Emilia
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- METO Agron
- Department of Therapy, Faculty of Dental Medicine, Aldent University
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- PEPPOLONI Samuele
- Department of Surgical, Medical, Dental and Morphological Sciences with interest in Transplant, Oncological and Regenerative Medicine; University of Modena and Reggio Emilia
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- BLASI Elisabetta
- Department of Surgical, Medical, Dental and Morphological Sciences with interest in Transplant, Oncological and Regenerative Medicine; University of Modena and Reggio Emilia School of Specialization in Microbiology and Virology, University of Modena and Reggio Emilia
抄録
<p>Endodontic biofilm is a microbial community, enclosed in a polymeric matrix of polysaccharide origin where are found pathogens, like bacteria and opportunistic fungi responsible for various endodontic pathologies. As clinical importance is the fact, that biofilm is extremely resistant to common intracanal irrigants, antimicrobial drugs and host immune responses. The aim of this study was to evaluate the in vitro efficacy of a Cu/CaOH2-based endodontic paste, against bacteria and fungi, such as Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans. We found that such compound significantly reduced microbial replication time and cell growth. Moreover, biofilm formation and persistence were also affected; treated biofilms showed both a reduced number of cells and levels of released pyoverdine. This study provides the first evidence on effectiveness of this endodontic compound against microbial biofilms. Given its wide range of action, its use in prevention and treatment of the main oral biofilm-associated infections will be discussed.</p>
収録刊行物
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- Dental Materials Journal
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Dental Materials Journal 38 (4), 591-603, 2019-07-26
日本歯科理工学会