回腸吸収上皮細胞の形態および機能の変化  [in Japanese] Ileal Absorptive Cells Alter Its Morphology and Function  [in Japanese]

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Abstract

<p>吸収上皮細胞は小腸絨毛上皮の大部分を占め,腸管腔からの栄養や水分吸収において中心的役割を担う.小腸だけでなく,大腸にも同名の細胞が存在し,いずれも形態的に類似するが,管腔から吸収する栄養の種類や管腔側へのIgAの分泌の有無など,細胞が存在する部位によって異なる機能を営む.乳飲期の齧歯類では,機能面だけでなく,部位によって異なる形態的特徴を有する吸収上皮細胞が存在する.しかし,離乳を境に,吸収上皮細胞の形態的差異は消失する.本稿では特に,乳飲期齧歯類の回腸に存在する吸収上皮細胞に着目し,その時期による形態および機能の変化について,また,オルガノイド培養法で得られた吸収上皮細胞の超微形態について紹介したい.</p>

<p>The mucosal surface of intestine is mainly covered by absorptive cells (enterocytes) which absorb nutrients and water from its lumen. The cells are present throughout intestine and have common structural characterization; however, its function varies in its location. In the rodents, the absorptive cells have different feature between adult and suckling period. In the suckling rodents, the absorptive cells alter intracellular structure along with proximo-distal (canoniocaudal) axis. We focused on the absorptive cells of distal small intestine (ileum) in suckling rodents. The cells specialize for apical endocytosis of macromolecules from maternal milk. After weaning, the absorptive cells that have apical endocytic membrane system disappear in the epithelium. According to the unique property, we applied organoid technologies on ileum.</p>

Journal

  • KENBIKYO

    KENBIKYO 52(1), 35-39, 2017

    The Japanese Society of Microscopy

Codes

  • NII Article ID (NAID)
    130007689242
  • NII NACSIS-CAT ID (NCID)
    AA11917781
  • Text Lang
    JPN
  • ISSN
    1349-0958
  • NDL Article ID
    028288066
  • NDL Call No.
    Z16-896
  • Data Source
    NDL  J-STAGE 
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