Bone Marrow Invasion of Small Cell Neuroendocrine Carcinoma of the Endometrium: A Diagnostic Pitfall Mimicking a Haematological Malignancy
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- Kawashima Ichiro
- Department of Hematology and Oncology, University of Yamanashi, Japan
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- Fukasawa Hiroko
- Department of Obstetrics and Gynecology, University of Yamanashi, Japan
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- Kasai Kazunari
- Department of Pathology, University of Yamanashi, Japan
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- Kumagai Takuma
- Department of Hematology and Oncology, University of Yamanashi, Japan
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- Koshiishi Megumi
- Department of Hematology and Oncology, University of Yamanashi, Japan
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- Nakajima Kei
- Department of Hematology and Oncology, University of Yamanashi, Japan
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- Kondo Tetsuo
- Department of Pathology, University of Yamanashi, Japan
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- Hashi Akihiko
- Department of Obstetrics and Gynecology, University of Yamanashi, Japan
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- Hirata Shuji
- Department of Obstetrics and Gynecology, University of Yamanashi, Japan
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- Kirito Keita
- Department of Hematology and Oncology, University of Yamanashi, Japan
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Abstract
<p>Metastasis of cancer cells to the bone marrow is relatively rare, despite being one of the most important causes of myelosuppression in patients with solid tumours. A bone marrow examination via a biopsy is the standard method of diagnosing cancer cell invasion into the bone marrow. However, it is sometimes challenging to distinguish neuroendocrine carcinoma cells from haematopoietic cells due to their small, round shape and chromosomal abnormalities resembling haematological malignancies. We herein report a case of bone marrow invasion of small cell neuroendocrine carcinoma of the endometrium mimicking therapy-related myeloid malignancy. </p>
Journal
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- Internal Medicine
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Internal Medicine 58 (17), 2561-2568, 2019-09-01
The Japanese Society of Internal Medicine