細胞表層のドメイン構造と細胞運動  [in Japanese] The Role of Plasma Membrane Domains in Cell Adhesion and Migration  [in Japanese]

Access this Article

Author(s)

Abstract

<p>細胞運動は,がん細胞などに顕著に認められ,細胞外マトリックスとの相互作用を通して調節される.近年,細胞膜に存在する微細な機能ドメインの役割が大きな注目を集めている.特に,脂質ラフト(lipid raft)は細胞膜における細胞内外の情報変換の中心的な部位であると考えられており,細胞接着・細胞運動を司るタンパク質が存在する.本稿では,脂質ラフトの細胞運動における役割に焦点を当て,大気圧走査電子顕微鏡(ASEM)を用いた成果を交えて論考した.</p>

<p>The dynamic features of the cancer cell surface may modulate the malignant phenotype of cancer, including adhesion disorders and aggressive phenotypes of migration. Lipid rafts are cholesterol-enriched microdomains of the cell membrane and possess a highly dynamic nature. They have been involved in various cellular functions including the regulation of cell adhesion and membrane signaling through proteins within lipid rafts. Recently, it was demonstrated that lipid rafts play critical roles in cancer cell adhesion and migration. This article summarizes the important roles of lipid rafts in cancer cell adhesion and migration, with a focus on the current state of knowledge. This article will improve the understanding of cancer progression and lead to the development of novel targets for cancer therapy.</p>

Journal

  • KENBIKYO

    KENBIKYO 49(1), 10-13, 2014

    The Japanese Society of Microscopy

Codes

  • NII Article ID (NAID)
    130007701780
  • NII NACSIS-CAT ID (NCID)
    AA11917781
  • Text Lang
    JPN
  • ISSN
    1349-0958
  • NDL Article ID
    025543048
  • NDL Call No.
    Z16-896
  • Data Source
    NDL  J-STAGE 
Page Top