Elaeagnus mollis Oil Attenuates Non-alcoholic Fatty Disease in High-fat Diet Induced Obese Mice via Modifying the Expression of Lipid Metabolism-related Genes
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- Guo Caixia
- School of Life Science, Shanxi University
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- Qiao Jinping
- School of Life Science, Shanxi University
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- Zhang Shengwan
- School of Life Science, Shanxi University
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- Li Meiping
- School of Life Science, Shanxi University
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- Li Juan
- Shanxiqierkang samara biological products co. ltd
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- Hatab Shaimaa
- Faculty of Agriculture and Environmental Science, Arish University
書誌事項
- タイトル別名
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- <i>Elaeagnus mollis</i> Oil Attenuates Non-alcoholic Fatty Disease in High-fat Diet Induced Obese Mice via Modifying the Expression of Lipid Metabolismrelated Genes
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<p>Elaeagnus mollis oil (EMO), which is a type of plant oil, was extracted from the nuts of Elaeagnus mollis Diels that is known as a precious woodyoilcrop in China. The present study investigated the ameliorative effects of EMO on high-fat diet-induced non-alcoholic fatty liver disease (NAFLD) and explored relative regulation mechanism. The analysis of EMO fatty acids showed that EMO rich in unsaturated fatty acids (92.07%), such as linoleic acid (48.24%), oleic acid (34.20%) and linolenic acid (7.57%). In addition, supplementation of EMO could ameliorate the increase in body weight, fat weight, and abnormal serum lipids induced by high-fat diet. A further important implication is that the levels of serum ALT, serum AST, hepatic TG, TC, SOD, GSH/GSSG ration and MDA were improved after supplementing with EMO. All these changes may be due to the ability of EMO to inhibit fatty acid synthesis via reducing the mRNA expression of SREBP-1c, PPARγ and FAS, and elevate fatty acid oxidation by increasing the mRNA expression of PPARα and CPT-1. Meanwhile, our results also showed that endogenously synthesized n-3 PUFAs could significantly increase after treating with EMO. In conclusion, the results suggested that EMO could be regarded as a healthy food for preventing NAFLD.</p>
収録刊行物
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- Journal of Oleo Science
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Journal of Oleo Science 68 (9), 893-908, 2019
公益社団法人 日本油化学会
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詳細情報 詳細情報について
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- CRID
- 1390845702276257280
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- NII論文ID
- 130007701987
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- NII書誌ID
- AA11503337
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- ISSN
- 13473352
- 13458957
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- NDL書誌ID
- 029904634
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- PubMed
- 31413241
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可