Strategies to Overcome Residual Risk During Statins Era

• Cho Kyoung Im

  Department of Cardiology, Kosin University Gospel Hospital

• Yu Jongwook

  Department of Cardiovascular Medicine, Heart Center, Gachon University Gil Medical Center

• Hayashi Toshio

  School of Health Sciences, Nagoya University Graduate School of Medicine

• Han Seung Hwan

  Department of Cardiovascular Medicine, Heart Center, Gachon University Gil Medical Center Gachon Cardiovascular Research Institute

• Koh Kwang Kon

  Department of Cardiovascular Medicine, Heart Center, Gachon University Gil Medical Center Gachon Cardiovascular Research Institute

Abstract

At present, atherosclerosis is one of the most important field in clinical and research medicine. Because it is closely related to cardiovascular (CV) and endocrine disorders such as coronary artery disease, cardiometabolic disorders, much research on how to manage atherosclerosis has been performed. The low-density lipoprotein cholesterol (LDL-C) concentration has been established as an independent risk factor for developing atherosclerosis, and considerable effort has been committed to educating both physicians and the general public on the importance of lowering LDL-C with statins. Although statins have already significantly improved CV outcomes, patients with LDL-C target levels achieved by intense statin therapy still have significant remaining CV risk. Statins already play a central role in managing hyperlipidemia; however, residual risk with statins is an important field of managing remaining CV risk. Recent studies have suggested residual cholesterol and inflammation risks in causing CV events. In the current review, we will discuss residual risk and suggest strategies to overcome it in the statins era.

Journal

• Circulation Journal

  Circulation Journal 83 (10), 1973-1979, 2019-09-25

  The Japanese Circulation Society

Keywords

• Cardiovascular diseases
• Cholesterol
• Inflammation
• Residual risk
• Statins

Details

• CRID: 1390564227306818688
• NII Article ID: 130007711586
• NII Book ID: AA11591968
• DOI: 10.1253/circj.cj-19-0624
• ISSN: 13474820
• ISSN: 13469843
• NDL BIB ID: 029974745
• PubMed: 31391351
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I029974745
• Web Site: https://www.jstage.jst.go.jp/article/circj/83/10/83_CJ-19-0624/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2020205541
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed