Development of regenerative medicine for kidney diseases using nephron progenitor cells

• Araoka Toshikazu

  Center for iPS Cell Research and Application(CiRA), Kyoto University

Bibliographic Information

Other Title

• ネフロン前駆細胞を用いた腎疾患に対する再生医療の開発

Abstract

In this article, we focus on the kidney regenerative research field and outline the latest research results. We first explain the history of nephron progenitor cells (NPCs) that are the basis of kidney organoid production. Next, we summarize the development of expansion culture method of NPCs derived from mouse embryonic kidney (mNPCs) and human induced pluripotent stem (iPS) cell-derived NPCs (hiPSC-NPCs), and the current status of cell therapies for acute kidney injury (AKI) via paracrine factors secreted by mNPCs and hiPSC-NPCs. Finally, we discuss the future perspectives of cell therapies and other possible applications using hiPSC-NPCs against kidney diseases.

Journal

• Organ Biology

  Organ Biology 26 (2), 163-174, 2019

  The Japan Society for Organ Preservation and Biology

Keywords

• nephron progenitor cell
• iPS cell
• regenerative medicine
• cell therapy
• expansion culture
• purification method

Details

• CRID: 1390845702285519872
• NII Article ID: 130007716038
• DOI: 10.11378/organbio.26.163
• ISSN: 21880204
• ISSN: 13405152
• Web Site: https://search.jamas.or.jp/link/ui/2020036045
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed