Simultaneous Presentation of Lymphomatoid Granulomatosis and Multiple myeloma in an Immunodeficient Patient with Rheumatoid Arthritis
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- Lee Shin
- Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Japan
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- Negoro Eiju
- Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Japan
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- Oki Hisashi
- Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, University of Fukui, Japan
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- Imamura Yoshiaki
- Division of Surgical Pathology, University of Fukui Hospital, Japan
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- Yamauchi Takahiro
- Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Japan
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Abstract
<p>A 75-year-old Japanese woman with a 20-year history of rheumatoid arthritis presented with symptomatic bilateral pleural effusion and lung and brain tumors. She had received methotrexate for five years and tacrolimus for one year. A brain biopsy specimen showed the pathological features of lymphoproliferative disease, but a bone marrow biopsy showed proliferation of plasma cells. She was finally diagnosed with coexistent lymphomatoid granulomatosis (LYG) of the brain and lung and multiple myeloma (MM) of the bone marrow and received chemotherapy for both. This report shows that immunodeficient patients are at risk of developing the unusual coexistence of LYG and MM. </p>
Journal
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- Internal Medicine
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Internal Medicine 58 (19), 2845-2849, 2019-10-01
The Japanese Society of Internal Medicine