A Selection Table for Information on Heparinoid-Containing Preparation

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  • Ishiwatari Ryoko
    Division of Practical Pharmacy, Keio University Faculty of Pharmacy
  • Enoki Yuki
    Division of Pharmacodynamics, Keio University Faculty of Pharmacy
  • Yokoyama Yuta
    Division of Practical Pharmacy, Keio University Faculty of Pharmacy
  • Taguchi Kazuaki
    Division of Pharmacodynamics, Keio University Faculty of Pharmacy
  • Kizu Junko
    Division of Practical Pharmacy, Keio University Faculty of Pharmacy
  • Matsumoto Kazuaki
    Division of Practical Pharmacy, Keio University Faculty of Pharmacy Division of Pharmacodynamics, Keio University Faculty of Pharmacy

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  • ヘパリン類似物質含有製剤の選択に有用な情報構築に関する検討

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Abstract

<p>We evaluated heparinoid-containing soft ointments and heparinoid-containing creams to develop information useful to select drugs. Spreadability, consistency and the water content of stratum corneum was measured. A selection table focusing on impression of the use was prepared. Spreadability of the semi-original soft ointment and cream were lower than those of all generic drugs. Regarding hardness, one generic soft ointment was softer than the semi-original drug, but the semi-original cream was harder than all generic creams. Regarding the impression of the use, a significant difference was noted in smell in soft ointments, and 6 items in creams. Correlation was found between the spreadability and consistency test results and impression of the use. A significant difference was noted in the water content of stratum corneum in creams. The selection table prepared based on the impression of the use may provide information that helps selection of preparations in clinical practice.</p>

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