A System on Artificial Cell Membrane: from Information Science to Biomedical Applications

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  • Takeuchi Nanami
    Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology（TUAT）
  • Izumi Kayano
    Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology（TUAT）
  • Shoji Kan
    Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology（TUAT） Department of Chemistry, University of Cincinnati
  • Kawano Ryuji
    Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology（TUAT）

Bibliographic Information

Other Title
  • 人工細胞膜システムの構築：情報科学から医療応用まで
  • ジンコウ サイボウマク システム ノ コウチク : ジョウホウ カガク カラ イリョウ オウヨウ マデ

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Abstract

This review describes the construction of artificial cell membrane and its applications. Planar lipid bilayers are used for functional studies of ion channels and nanopore sensing. We have used microfabrication and microfluidic technologies that have a significant advantage: easy to handle lipid molecules or solution at the micron scale. Applying these advantages, we propose a stable and reproducible preparation procedure for the planar lipid bilayers using “droplet contact method”, and they are applying to extensive applications, such as assay for transmembrane peptides, microRNA detection with DNA computing, and ion conductance probe.

Journal

  • MEMBRANE

    MEMBRANE 44 (5), 239-246, 2019

    THE MEMBRANE SOCIETY OF JAPAN

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