Increased activity of lipoprotein-associated phospholipase A2 in non-severe asthma
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- Kuczia Pawel
- Department of Internal Medicine, Jagiellonian University Medical College
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- Mastalerz Lucyna
- Department of Internal Medicine, Jagiellonian University Medical College
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- Potaczek Daniel P.
- John Paul II Hospital Institute of Laboratory Medicine, Member of the German Center for Lung Research (DZL), Universities of Giessen and Marburg Lung Center (UGMLC), Philipps-Universität Marburg
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- Cybulska Agnieszka
- Department of Internal Medicine, Jagiellonian University Medical College
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- Zareba Lech
- Faculty of Mathematics and Natural Sciences, University of Rzeszow
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- Bazan-Socha Stanislawa
- Department of Internal Medicine, Jagiellonian University Medical College
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- Undas Anetta
- Department of Internal Medicine, Jagiellonian University Medical College John Paul II Hospital Institute of Cardiology, Jagiellonian University Medical College
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- タイトル別名
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- Increased activity of lipoprotein-associated phospholipase A<sub>2</sub> in non-severe asthma
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<p>Background: Given increased risk of cardiovascular events in asthma we hypothesized that lipoprotein-associated phospholipase A2 (Lp-PLA2), an enzyme involved in atherosclerosis, is associated with proinflammatory and prothrombotic blood alterations in this disease.</p><p>Methods: In 164 adult asthmatics (63 with severe asthma) we measured plasma Lp-PLA2 activity using the PLAC test. We determined its relations to inflammation and prothrombotic blood alterations.</p><p>Results: In asthma, Lp-PLA2 was inversely related to the age (β = -0.1 [-0.18 to -0.02]) and was lower in women (n = 122 [74%], 205 [182-242] vs. 243 [203-262] nmol/min/ml, p = 0.001). Interestingly, Lp-PLA2 correlated negatively with the asthma severity score (β = -0.15 [-0.23 to -0.07]), being 10.3% higher in those with non-severe (mild or moderate) asthma (n = 101, 62%) as compared to the severe disease subtype (224 [191-261] vs. 203 [181-229], p = 0.006 after adjustment for potential confounders). Lp-PLA2 activity was positively related to the levels of low-density lipoprotein (β = 0.1 [0.02-0.18]), triglycerides (β = 0.11 [0.03-0.19]) and glucose (β = 0.1 [0.02-0.18]) and inversely to the tumor necrosis factor α (β = -0.27 [-0.35 to -0.2]), high sensitivity C-reactive protein (β = -0.1 [-0.19 to -0.02]) and fibrinogen (β = -0.12 [-0.21 to -0.03]), as well as prothrombin (β = -0.16 [-0.24 to -0.08]), and parameters describing thrombin generation potential, such as endogenous thrombin potential (β = -0.14 [-0.21 to -0.06]) and peak thrombin generated (β = -0.2 [-0.28 to -0.12]).</p><p>Conclusions: Elevated Lp-PLA2 activity in non-severe asthmatics suggests increased atherosclerotic risk in this group. Lower Lp-PLA2 activity accompanied by its inverse relationship to inflammatory or prothrombotic blood biomarkers observed in turn in severe asthmatics might be related to the pathogenesis of more severe asthma phenotype.</p>
収録刊行物
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- Allergology International
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Allergology International 68 (4), 450-455, 2019
一般社団法人日本アレルギー学会
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詳細情報 詳細情報について
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- CRID
- 1390001277374220800
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- NII論文ID
- 130007733153
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- ISSN
- 14401592
- 13238930
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- CiNii Articles
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- 使用不可