Butyryl-CoA:acetate CoA-transferase gene associated with the genus <i>Roseburia</i> is decreased in the gut microbiota of Japanese patients with ulcerative colitis

• SHINOHARA Ryohei

  Division Food and Drug Evaluation Science, Department of Social/Community Medicine and Health Science, Graduate School of Medicine, Kobe University, 7-5-2 Kusunoki-cho Chuo-ku, Kobe, Hyogo 650-0017, Japan

• SASAKI Kengo

  Graduate School of Science, Technology and Innovation, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe, Hyogo 657-8501, Japan

• INOUE Jun

  Division of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan

• HOSHI Namiko

  Division of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan

• FUKUDA Itsuko

  Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe, Hyogo 657-8501, Japan Research Center for Food Safety and Security, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe, Hyogo 657-8501, Japan

• SASAKI Daisuke

  Graduate School of Science, Technology and Innovation, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe, Hyogo 657-8501, Japan

• KONDO Akihiko

  Graduate School of Science, Technology and Innovation, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe, Hyogo 657-8501, Japan RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan

• OSAWA Ro

  Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe, Hyogo 657-8501, Japan Research Center for Food Safety and Security, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe, Hyogo 657-8501, Japan

Abstract

Microbial production of butyrate is impaired in patients with ulcerative colitis (UC); however, this inhibition is not well understood in Japanese UC patients. Therefore, we quantitatively analyzed genes encoding butyryl-CoA:acetate CoA-transferase (but) and butyrate kinase (buk) in the gut microbiota of Japanese patients with UC and healthy volunteers (HVs). But showed higher levels than buk. Moreover, patients with UC showed significantly decreased levels of but associated with Roseburia sp./Eubacterium rectale compared with HVs. But, which is associated with Faecalibacterium sp., was maintained in patients with UC, with an unchanged relative abundance of Faecalibacterium sp. microorganisms in patients with UC compared with HVs.

Journal

• Bioscience of Microbiota, Food and Health

  Bioscience of Microbiota, Food and Health 38 (4), 159-163, 2019

  BMFH Press

Keywords

• microbiota
• ulcerative colitis
• butyrate
• butyryl-CoA:acetate CoA-transferase
• <i>Roseburia</i> sp.
• <i>Faecalibacterium</i> sp.

Details

• CRID: 1390282752354071936
• NII Article ID: 130007738831
• DOI: 10.12938/bmfh.18-029
• ISSN: 21863342
• HANDLE: 20.500.14094/90008680
• Web Site: https://www.jstage.jst.go.jp/article/bmfh/38/4/38_18-029/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2020223969
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed