Explore the correlation between ARID1A and ANXA1 expressions in gastric cancer
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- Yamada Leo
- Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine
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- Saito Motonobu
- Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine
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- Thar Min Aung Kyi
- Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine
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- Saito Katsuharu
- Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine
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- Kase Koji
- Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine
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- Onozawa Hisashi
- Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine
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- Okayama Hirokazu
- Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine
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- Fujita Shotaro
- Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine
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- Endo Hisahito
- Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine
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- Sakamoto Wataru
- Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine
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- Saze Zenichiro
- Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine
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- Momma Tomoyuki
- Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine
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- Ohki Shinji
- Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine
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- Mimura Kosaku
- Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine
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- Kono Koji
- Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine
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Abstract
<p>Gastric cancer is leading cause of death worldwide. Although several therapeutic agents have been developed and showed positive efficacy for patients with gastric cancer, drug resistance remains severe problem during treatment. AT-rich interactive domain 1A (ARID1A) and annexin A1 (ANXA1) have a pivotal role in gastric tumorigenesis and reported as useful predictive or prognostic biomarkers. Previous study revealed that loss of ARID1A confers resistance to drugs that target the HER2/PI3K/mTOR pathway in breast cancer through activation of AKT via upregulation of ANXA1. Elevated ANXA1 levels are important for trastuzumab resistance and ANXA1 expression is inversely correlated with ARID1A levels in HER2-positive breast cancer. While trastuzumab is also used in HER2-positive gastric cancer, the expression status between ARID1A and ANXA1 in gastric cancer has yet to be determined. Here, we investigated both ARID1A and ANXA1 expressions by immunohistochemical staining in the test (n = 200) and validation (n = 220) cohorts of gastric cancer. Our results revealed that the inverse correlation between ARID1A and ANXA1 was not exist in patients with gastric cancer. The mRNA microarray analysis, which identified ARID1A-regulated genes in HER2-positive gastric cancer cells, revealed that ANXA1 was not induced by ARID1A knockdown. The present study suggested that the molecular relationship between ARID1A and ANXA1 is different in gastric cancer from in the breast cancer that ANXA1 serves as a predictive biomarker for trastuzumab-based treatment. Our results prompt a further study into the investigation of functional role of ARID1A and ANXA1 in gastric cancer.</p>
Journal
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- Annals of Cancer Research and Therapy
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Annals of Cancer Research and Therapy 27 (2), 46-51, 2019-07-30
The Japanese Society of Strategies for Cancer Research and Therapy
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Keywords
Details 詳細情報について
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- CRID
- 1390845702309398144
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- NII Article ID
- 130007739091
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- ISSN
- 18805469
- 13446835
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed