Slc:Hartley guinea pigs frequently possess duplication of the caudal vena cava

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  • Nakamura Teppei
    Section of Biological Science, Chitose Laboratory, Japan Food Research Laboratories, 2-3 Bunkyo, Chitose, Hokkaido 066-0052, Japan Laboratory of Anatomy, Department of Basic Veterinary Sciences, Division of Veterinary Medicine, Faculty of Veterinary Medicine, Hokkaido University, Kita 18-Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan
  • Norimura Miyuki
    Section of Biological Safety Research, Chitose Laboratory, Japan Food Research Laboratories, 2-3 Bunkyo, Chitose, Hokkaido 066-0052, Japan
  • Sumi Kanako
    Section of Biological Safety Research, Chitose Laboratory, Japan Food Research Laboratories, 2-3 Bunkyo, Chitose, Hokkaido 066-0052, Japan
  • Ichii Osamu
    Laboratory of Anatomy, Department of Basic Veterinary Sciences, Division of Veterinary Medicine, Faculty of Veterinary Medicine, Hokkaido University, Kita 18-Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan
  • Elewa Yaser Hosny Ali
    Laboratory of Anatomy, Department of Basic Veterinary Sciences, Division of Veterinary Medicine, Faculty of Veterinary Medicine, Hokkaido University, Kita 18-Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan Department of Histology and Cytology, Faculty of Veterinary Medicine, Zagazig University, Qesm Awal Az Zagazig, Ash Sharqia Governorate 44519, Egypt
  • Kon Yasuhiro
    Laboratory of Anatomy, Department of Basic Veterinary Sciences, Division of Veterinary Medicine, Faculty of Veterinary Medicine, Hokkaido University, Kita 18-Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan
  • Tatsumi Osamu
    Section of Biological Science, Chitose Laboratory, Japan Food Research Laboratories, 2-3 Bunkyo, Chitose, Hokkaido 066-0052, Japan
  • Hattori Hideki
    Section of Biological Safety Research, Chitose Laboratory, Japan Food Research Laboratories, 2-3 Bunkyo, Chitose, Hokkaido 066-0052, Japan
  • Yoshiyasu Tomoji
    Section of Biological Safety Research, Chitose Laboratory, Japan Food Research Laboratories, 2-3 Bunkyo, Chitose, Hokkaido 066-0052, Japan
  • Nagasaki Ken-ichi
    Section of Biological Safety Research, Tama Laboratory, Japan Food Research Laboratories, 6-11-10 Nagayama, Tama, Tokyo 206-0025, Japan

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Abstract

<p>The formation of the caudal vena cava is a complex process involving development, regression, and anastomosis. In mammals, the normal caudal vena cava runs to the right side of the abdominal aorta, while duplication of the caudal vena cava has been identified as a congenital abnormality in both companion animals and humans. The present study demonstrates that Slc:Hartley guinea pigs frequently possess asymptomatic duplicated caudal vena cava. The prevalence was 30% and 24% for males and females, respectively, with no sex-related differences. In accordance with Saad et al. (2012)’s criteria, duplicated caudal vena cava were classified into two distinct variations. The dominant variation was a complete duplication without iliac anastomosis where the left caudal vena cava continued from the left common iliac vein and joined the left renal vein; the left renal vein ran to the right to join the right caudal vena cava. The alternative variation was an incomplete duplication where the left caudal vena cava joined the right infrarenal caudal vena cava at a more cranial point than in normal cases; the renal segment was unchanged. Iliac anastomosis was not found in any cases. Duplicated caudal vena cava neither affected the body weight nor the kidney weight. In conclusion, Slc:Hartley guinea pigs frequently possess asymptomatic duplicated caudal vena cava in the absence of iliac anastomosis and appear to be a novel and useful animal model for duplicated caudal vena cava in animals and humans.</p>

Journal

  • Experimental Animals

    Experimental Animals 68 (4), 465-470, 2019

    Japanese Association for Laboratory Animal Science

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