Development of Self-screening System for Oral Cancer
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- HAYAKAWA MANA
- Division of Oral and Maxillofacial Surgery, Department of Science of Physical Functions, Kyushu Dental University
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- HABU MANABU
- Division of Oral and Maxillofacial Surgery, Department of Science of Physical Functions, Kyushu Dental University
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- HARAGUCHI KAZUYA
- Division of Oral and Maxillofacial Surgery, Department of Science of Physical Functions, Kyushu Dental University
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- YADA NAOMI
- Division of Oral Pathology, Department of Health Promotion, Kyushu Dental University
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- SATO SHINOBU
- Department of Applied Chemistry, Kyushu Institute of Technology
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- TAKENAKA SHIGEORI
- Department of Applied Chemistry, Kyushu Institute of Technology
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- TOMINAGA KAZUHIRO
- Division of Oral and Maxillofacial Surgery, Department of Science of Physical Functions, Kyushu Dental University
Bibliographic Information
- Other Title
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- 口腔がん早期発見のための剝離細胞診を応用した自己検診システムの開発
- —An Optimal Method for Self-collection of Exfoliative Cells—
- —適切な細胞採取法の検討—
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Abstract
Previous studies conducted by our group confirmed that the electrochemical telomerase assay (ECTA) is sufficiently sensitive to detect oral cancer from the cells obtained by exfoliation from the whole oral cavity. In this study to develop a self-screening system for oral cancer using this method, we examined the optimal method for self-collection of exfoliated cells from the whole oral cavity.<br>First, an interdental brush, a conventional silicone brush for the cervix, a newly developed silicone brush for the oral cavity, a sponge brush used in our previous studies, and a gargle were tested for exfoliation from the oral cavity in ten healthy volunteers. Cells exfoliated from the oral cavity were collected by a single examiner, to prevent inter-examiner variation.<br>Then, exfoliated cells were collected from the same ten healthy volunteers by the same manner and stained using papanicolaou.<br>Finally, to mimic self-examination for oral cancer, another ten healthy volunteers were instructed on how to perform a specially-made protocol for collecting exfoliated cells from their oral cavity with a sponge brush, which had been evaluated in the initial study as the most efficient method. All subjects collected a sufficient number of cells comparable to conventional methods of exfoliative cytology.<br>In conclusion, the self-screening system for detecting oral cancer using ECTA with the cell collection protocol described herein could be promising.
Journal
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- Japanese Journal of Oral Diagnosis / Oral Medicine
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Japanese Journal of Oral Diagnosis / Oral Medicine 32 (3), 191-196, 2019
The Japanese Society of Oral Diagnosis / Oral Medicine
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Details 詳細情報について
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- CRID
- 1390001277385172608
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- NII Article ID
- 130007742331
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- ISSN
- 21882843
- 09149694
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed