書誌事項
- タイトル別名
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- MicroRNA and long non–coding RNA in neuropathic pain
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抄録
<p>Non–coding RNAs affect various cellular processes through interaction with DNA, RNA and protein. Accordingly, non–coding RNAs, microRNAs and more recently long non–coding RNAs, have been shown to be involved in pain disorders, including neuropathic pain. MicroRNAs inhibit translational step of gene expression and dysregulation of microRNAs underlies the neuropathic pain. On the other hand, lncRNAs regulate diverse steps of gene expression, including epigenetic modulation, transcription, alternative splicing and translation, although a role of lncRNAs in the pain disorders remain poorly understood. Interestingly, a part of non–coding RNAs are released to extracellular space and mediate a cell–cell communication. Extracellular microRNAs are shown to modulate nociceptive transmission. Furthermore, extracellular non–coding RNAs are expected as a specific biomarker for neuronal damage or pain in the blood. In this review, we summarize current insights into non–coding RNA significance in the neuropathic pain.</p>
収録刊行物
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- PAIN RESEARCH
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PAIN RESEARCH 34 (3), 219-227, 2019-09-20
日本疼痛学会
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詳細情報 詳細情報について
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- CRID
- 1390564227341768576
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- NII論文ID
- 130007742528
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- ISSN
- 21874697
- 09158588
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可