Hepatitis B virus recurrence after living donor liver transplantation of anti-HBc-positive grafts: A 22-year experience at a single center
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- Bae Sung Kwan
- Organ Transplantation Service, The University of Tokyo Hospital, Tokyo, Japan.
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- Akamatsu Nobuhisa
- Organ Transplantation Service, The University of Tokyo Hospital, Tokyo, Japan. Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
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- Togashi Junichi
- Organ Transplantation Service, The University of Tokyo Hospital, Tokyo, Japan. Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
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- Ichida Akihiko
- Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
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- Kawahara Takuya
- Biostatistics Division, Clinical Research Support Center, The University of Tokyo Hospital, Tokyo, Japan.
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- Maki Harufumi
- Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
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- Nishioka Yujiro
- Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
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- Kokudo Takashi
- Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
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- Mihara Yuichiro
- Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
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- Kawaguchi Yoshikuni
- Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
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- Ishizawa Takeaki
- Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
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- Arita Junichi
- Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
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- Kaneko Junichi
- Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
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- Tamura Sumihito
- Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
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- Hasegawa Kiyoshi
- Organ Transplantation Service, The University of Tokyo Hospital, Tokyo, Japan. Artificial Organ and Transplantation Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
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Abstract
<p>The use of hepatitis B core antibody (anti-HBc)-positive grafts is one strategy for expanding the donor pool for liver transplantation (LT). The aim of this study was to determine the risk factors associated with hepatitis B virus (HBV) recurrence after living donor LT (LDLT) of anti-HBc-positive grafts. From January 1996 to December 2018, a total of 609 LDLT procedures were performed at our center. A retrospective review was performed for 31 patients (23 males and 8 females; median age = 47 years) who underwent LDLT for HBV-unrelated liver disease from anti-HBc-positive donors. The factors associated with HBV recurrence were evaluated and compared between the HBV recurrence and non-recurrence groups. The median follow-up period after LT was 135 months (range, 6-273 months). Four of 31 patients (12.9%) developed post-LT HBV recurrence. All four cases were HBV-naïve patients (anti-HBc-negative and Hepatitis B surface antibody-negative). The median interval between LDLT and HBV recurrence was 42 months (range, 20-51). The overall actuarial rates of HBV recurrence at 1, 3, 5, 10, and 20 years were 0%, 7.2%, 15.7%, 15.7%, and 15.7%, respectively. Although there were no significant differences between the HBV recurrence and non-recurrence groups, HBV recurrence tended to occur in HBV-naïve recipients (P = 0.093). HBV-naïve status may contribute to HBV recurrence after LDLT for HBV-unrelated liver disease from anti-HBc-positive donors. Careful monitoring for serological HBV markers is needed, particularly in this group.</p>
Journal
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- BioScience Trends
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BioScience Trends 13 (5), 448-455, 2019-10-31
International Research and Cooperation Association for Bio & Socio-Sciences Advancement