Fluorescent Polystyrene Latex Nanoparticles for NIR-II <i>in vivo</i> Imaging

  • Kamimura Masao
    Department of Materials Science and Technology, Tokyo University of Science Imaging Frontier Center (IFC), Research Institute for Science and Technology (RIST), Tokyo University of Science
  • Ueya Yuichi
    Tsukuba Research Laboratories, JSR Corporation
  • Takamoto Eiji
    Tsukuba Research Laboratories, JSR Corporation
  • Iso Kazuhiro
    Tsukuba Research Laboratories, JSR Corporation
  • Yoshida Moe
    Department of Materials Science and Technology, Tokyo University of Science
  • Umezawa Masakazu
    Department of Materials Science and Technology, Tokyo University of Science Imaging Frontier Center (IFC), Research Institute for Science and Technology (RIST), Tokyo University of Science
  • Soga Kohei
    Department of Materials Science and Technology, Tokyo University of Science Imaging Frontier Center (IFC), Research Institute for Science and Technology (RIST), Tokyo University of Science

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  • Fluorescent Polystyrene Latex Nanoparticles for NIR-Ⅱ in vivo Imaging

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Abstract

<p>In this study, tissue-penetrable near infrared (NIR)-II fluorescent polystyrene latex nanoparticles (NIR-PSt NPs) were designed and prepared as deep tissue in vivo imaging probes. An NIR-II fluorescent dye was successfully loaded into PSt NPs. The resulting NIR-PSt NPs showed strong NIR-II (1100 nm) emission in an aqueous environment. In addition, in vivo imaging of live mice was successfully performed using these NIR-PSt NPs. The prepared NIR-PSt NPs exhibited remarkable properties for in vivo fluorescence imaging.</p>

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