Suppressive effects of whey protein hydrolysate on sucrose-induced hyperglycemia in silkworms
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- Matsumoto Yasuhiko
- Department of Microbiology, Meiji Pharmaceutical University, Tokyo, Japan. Teikyo University Institute of Medical Mycology, Tokyo, Japan.
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- Takahashi Miki
- Teikyo University Institute of Medical Mycology, Tokyo, Japan. Genome Pharmaceuticals Institute Co., Ltd., Tokyo, Japan.
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- Umehara Masahiro
- Health Science Research Center, Research and Development Institute, Morinaga and Company Limited, Kanagawa, Japan.
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- Asano Masato
- Health Science Research Center, Research and Development Institute, Morinaga and Company Limited, Kanagawa, Japan.
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- Maruki-Uchida Hiroko
- Health Science Research Center, Research and Development Institute, Morinaga and Company Limited, Kanagawa, Japan.
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- Morita Minoru
- Health Science Research Center, Research and Development Institute, Morinaga and Company Limited, Kanagawa, Japan.
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- Sekimizu Kazuhisa
- Teikyo University Institute of Medical Mycology, Tokyo, Japan. Genome Pharmaceuticals Institute Co., Ltd., Tokyo, Japan.
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抄録
<p>Silkworms are useful for evaluating substances that suppress postprandial hyperglycemia by oral administration. In this study, orally administered whey protein hydrolysate (WPH), obtained by enzymatic treatment of whey protein, suppressed sucrose-induced hyperglycemia in silkworms in a dose-dependent manner. WPH also inhibited glucose-induced hyperglycemia in silkworms. These findings suggest that WPH contains a bioactive peptide that inhibits glucose uptake from the intestinal tract and thereby suppresses sucrose-induced hyperglycemia.</p>
収録刊行物
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- Drug Discoveries & Therapeutics
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Drug Discoveries & Therapeutics 13 (5), 244-247, 2019-10-31
特定非営利活動法人 バイオ＆ソーシャル・サイエンス推進国際研究交流会