Characteristics of Cerebral Aneurysms in Japan

  • IKAWA Fusao
    Department of Neurosurgery, Shimane Prefectural Central Hospital
  • HIDAKA Toshikazu
    Department of Neurosurgery, Shimane Prefectural Central Hospital
  • YOSHIYAMA Michitsura
    Department of Neurosurgery, Shimane Prefectural Central Hospital
  • OHBA Hideo
    Department of Neurosurgery, Shimane Prefectural Central Hospital
  • MATSUDA Shingo
    Department of Neurosurgery, Shimane Prefectural Central Hospital
  • OZONO Iori
    Department of Neurosurgery, Shimane Prefectural Central Hospital
  • IIHARA Koji
    Department of Neurosurgery, Graduate School of Medical Sciences Kyushu University
  • KINOUCHI Hiroyuki
    Department of Neurosurgery, Faculty of Medicine, University of Yamanashi
  • NOZAKI Kazuhiko
    Department of Neurosurgery, Shiga University of Medical Science
  • KATO Yoko
    Department of Neurosurgery, Fujita Health University Bantane Hospital
  • MORITA Akio
    Department of Neurological Surgery, Nippon Medical School Hospital
  • MICHIHATA Nobuaki
    Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo
  • YASUNAGA Hideo
    Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo
  • KURISU Kaoru
    Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University

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Abstract

<p>The characteristics of cerebral aneurysms in Japan differ from other countries in the higher incidence of unruptured cerebral aneurysm detected by brain check-up screening, higher rupture rate of unruptured cerebral aneurysm, higher incidence of subarachnoid hemorrhage, and superior outcome after subarachnoid hemorrhage based on meta-analysis. Head shape, genetic features, environmental factors, demographics, and medical system in Japan are also different from other countries. Unruptured cerebral aneurysms are 2.8 times more likely to rupture in Japanese than western aneurysms, resulting in the highest incidence of subarachnoid hemorrhage in the world. The exact and specific mechanisms of de novo, growth, and rupture of cerebral aneurysms have not been elucidated. Investigations will contribute to the understanding of cerebral aneurysms and subarachnoid hemorrhage worldwide. Some features of cerebral aneurysm in Japan are discussed for possible research guidance in the elucidation of the predominance of subarachnoid hemorrhage in Japan.</p>

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