The Relationship between Circulating Polyunsaturated Fatty Acid Levels and Exercise Responses of Patients with Non-ischemic Heart Failure

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  • Izumida Seiya
    Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
  • Kawano Hiroaki
    Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
  • Muroya Takahiro
    Department of Cardiology, Sasebo City General Hospital, Japan
  • Motokawa Tetsufumi
    Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
  • Akashi Ryohei
    Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
  • Yonekura Tsuyoshi
    Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
  • Morimoto Yosuke
    Department of Rehabilitation, Nagasaki University Hospital, Japan
  • Yano Yudai
    Department of Rehabilitation, Nagasaki University Hospital, Japan
  • Ikeda Satoshi
    Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
  • Maemura Koji
    Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan

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<p>Objective Polyunsaturated fatty acids (PUFAs) are associated with heart failure (HF) as well as coronary artery disease. However, little is known about the relationships between PUFAs and the exercise responses of patients with HF. We evaluated the relationships between PUFAs and the parameters of cardiopulmonary exercise tests (CPETs) in patients with non-ischemic HF. </p><p>Methods Fifty patients with stable non-ischemic HF underwent CPETs at our hospital. Data were analyzed to evaluate the relationships between PUFAs and echocardiographic findings as well as CPET and other test parameters. </p><p>Results Correlations were significant and negative between dihomo-γ-linolenic acid (DGLA) + arachidonic acid (AA) and minute ventilation versus carbon dioxide production (VE/VCO2) slope, and positive between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and VE/VCO2 slope. A multivariate regression analysis selected DGLA+AA and AA as independent predictors of VE/VCO2 slope. However, eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) were not significantly correlated with the CPET parameters. </p><p>Conclusion Low levels of circulating DGLA+AA and AA among PUFAs were associated with decreased exercise responses in patients with stable non-ischemic HF. These findings suggest that high levels of omega-6 PUFAs may improve the clinical outcomes of patients with non-ischemic HF via their effects on exercise responses. </p>

収録刊行物

  • Internal Medicine

    Internal Medicine 58 (22), 3219-3225, 2019-11-15

    一般社団法人 日本内科学会

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