ビスフォスフォネート製剤の不適切な服用方法による発症が疑われた口腔粘膜潰瘍

DOI Web Site Web Site 参考文献17件 オープンアクセス
  • 新田 哲也
    鹿児島市立病院歯科口腔外科
  • 坂元 亮一
    今村総合病院歯科口腔外科
  • 平原 成浩
    鹿児島市立病院歯科口腔外科
  • 松村 吉晃
    鹿児島大学大学院医歯学総合研究科先進治療科学専攻顎顔面機能再建学講座顎顔面疾患制御学
  • 中村 康大
    鹿児島大学大学院医歯学総合研究科先進治療科学専攻顎顔面機能再建学講座顎顔面疾患制御学
  • 後藤 雄一
    鹿児島大学大学院医歯学総合研究科先進治療科学専攻顎顔面機能再建学講座顎顔面疾患制御学

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タイトル別名
  • Oral ulcers suspected to be caused by improper administration of bisphosphonate
  • ビスフォスフォネート セイザイ ノ フテキセツ ナ フクヨウ ホウホウ ニ ヨル ハッショウ ガ ウタガワレタ コウコウ ネンマク カイヨウ

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<p>The side effects of peroral bisphosphonate may cause mucous membrane disorders and oral exulceration if individuals dissolve the drug inside the oral cavity on oral administration. We experienced two cases in which we strongly suspected mucous ulcurs due to this drug. Finally, the oral exulceration disappeared after providing instructions on correct administration.</p><p> An 83-year-old woman was referred because of exulceration of the right mandible. She suffered from osteoporosis, thoracic vertebra compression fracture, and dementia, while taking alendronate weekly. The exulceration appeared from the right lower lip to the right mandibular molar gingiva when we absorbed pooled saliva in the right oral cavity when the patient was lying down. We instructed the patient to confirm that the tablet was completely swallowed. The ulcers in the oral cavity completely disappeared 17 days after presentation.</p><p> A 74-year-old woman with osteoporosis presented because of bleeding and pain in the gingiva of the right mandible. She was taking monthly minodronate while wearing incompatible dentures. Exulceration occurred with peripheral redness ranging from the right buccal mucosa to the right molar gingiva of the mandible and the tongue/floor of her mouth, along with a ventrolateral tongue. We taught her how to swallow minodoronate correctly without dentures, and the ulcers healed 4 weeks later.</p>

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