スフィンゴ糖脂質の脂質ラフトによる病原体認識応答機構

• Nakayama Hitoshi

  Laboratory of Biochemistry, Juntendo University Faculty of Health Care and Nursing Institute for Environmental and Gender-specific Medicine, Juntendo University Graduate School of Medicine

• Iwabuchi Kazuhisa

  Laboratory of Biochemistry, Juntendo University Faculty of Health Care and Nursing Institute for Environmental and Gender-specific Medicine, Juntendo University Graduate School of Medicine Infection Control Nursing, Juntendo University Graduate School of Health Care and Nursing

書誌事項

タイトル別名

• Glycosphingolipid-Enriched Lipid Rafts-Mediated Pathogen Recognition Systems

抄録

Phagocytes, such as neutrophils, macrophages and dendritic cells, play crucial roles in the innate immune system. Innate immune responses are initiated by the binding of pathogens expressing highly conserved pathogen-associated molecular patterns (PAMPs) to a diverse array of pattern-recognition receptors (PRRs) expressed by phagocytes. On phagocytes, glycosphingolipids (GSLs) cluster together with cholesterol, glycophosphatidylinositol-anchored proteins, and various signaling molecules to form GSL-enriched lipid rafts. These GSL-enriched lipid rafts bind to several types of pathogens and their PAMPs, suggesting that these lipid rafts are essential for host-pathogen interactions in innate immunity. The neutral GSL lactosylceramide (LacCer, CDw17) binds to various microorganisms, including Candida and Mycobacteria. LacCer is expressed on plasma and granular membranes of mature human neutrophils and forms lipid rafts together with members of the Src family tyrosine kinases. These LacCer-enriched lipid rafts can mediate migration, phagocytosis of non-opsonized microorganisms and superoxide generation. On plasma membranes, LacCer-enriched lipid rafts serve as signal transduction platform for CD11b/CD18 integrin (Mac-1, CR3, or α_Mβ₂-integrin), indicating the importance of LacCer in a wide range of human innate immune responses. Especially, the interactions between LacCer-enriched lipid rafts and mycobacterial lipoarabinomannan (LAM) are significant for neutrophil phagocytosis of non-opsonized mycobacteria in human. We describe here the functional role of LacCer-enriched lipid rafts in human phagocytes.

収録刊行物

• Ｔｒｅｎｄｓ　ｉｎ　Ｇｌｙｃｏｓｃｉｅｎｃｅ　ａｎｄ　Ｇｌｙｃｏｔｅｃｈｎｏｌｏｇｙ

  Ｔｒｅｎｄｓ　ｉｎ　Ｇｌｙｃｏｓｃｉｅｎｃｅ　ａｎｄ　Ｇｌｙｃｏｔｅｃｈｎｏｌｏｇｙ 31 (184), E141-E149, 2019-11-25

  FCCA(Forum: Carbohydrates Coming of Age)

キーワード

• lactosylceramide
• phagocyte
• Mycobacteria
• lipoarabinomannan
• β-glucan

詳細情報

• CRID: 1390282752372929536
• NII論文ID: 40022253883
• NII論文ID: 130007751003
• NII論文ID: 130007751012
• NII書誌ID: AA10995236
• DOI: 10.4052/tigg.1766.1e
• DOI: 10.4052/tigg.1766.1j
• ISSN: 18832113
• ISSN: 09157352
• NDL書誌ID: 030450778
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I030450778
• Web Site: https://www.jstage.jst.go.jp/article/tigg/31/184/31_1766.1E/_pdf
• Web Site: https://www.jstage.jst.go.jp/article/tigg/31/184/31_1766.1J/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可