Vestibular Schwannoma (VS)—Basic research and genetic analysis

DOI
  • Fujita Takeshi
    Department of Otorhinolaryngology – Head and Neck Surgery, Kobe University Graduate School of Medicine Department of Otolaryngology, Kindai University Faculty of Medicine
  • Doi Katsumi
    Department of Otolaryngology, Kindai University Faculty of Medicine

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Other Title
  • 聴神経腫瘍の基礎研究と遺伝子解析

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Abstract

<p>Vestibular schwannomas (VSs), known as acoustic neuromas, arise from the myelin-producing Schwann cells of the vestibular nerves in the VIIIth cranial nerve. Bilateral VSs associated to neurofibromatosis type II are rare. On the other hand, recent studies revealed that sporadic VSs are more common than previously thought according with the development of clinical imaging and prolonged life span. However, the mechanisms of tumor growth and sensorineural hearing loss associated with VSs are poorly understood so far.</p><p>Pharmacotherapeutic options have been developing after discovering the efficacy of bevacizumab, an anti-VEGF antibody, for NF2-related bilateral VSs reported. Here we report an overview of the VS basic research and introduce our studies on VSs.</p>

Journal

  • Otology Japan

    Otology Japan 29 (2), 137-141, 2019

    Japan Otological Society

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