Investigation on the relationship between anti–parkinsonian drugs and excessive daytime sleepiness/sudden onset sleep

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  • Ando Rina
    Department of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine
  • Tada Satoshi
    Department of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine
  • Miyaue Noriyuki
    Department of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine
  • Yabe Hayato
    Department of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine
  • Nomoto Masahiro
    Department of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine
  • Nagai Masahiro
    Department of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine

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  • Parkinson病治療薬と日中の眠気・突発的睡眠との関連についての検討

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Abstract

<p>Objective</p><p>Some of patients with Parkinson's disease (PD) have experienced excessive daytime sleepiness. It is reported that the anti–parkinsonian drugs is one of risk factors of excessive daytime sleepiness, we, therefore, investigated the association between anti–parkinsonian drugs and daytime sleepiness with PD patients.</p><p>Methods</p><p>PD patients who visited our clinic were studied. PD patients were interviewed on daytime sleepiness using Epworth Sleepiness Scale (ESS) and experience of sudden onset sleep by neurologists and a trained nurse.</p><p>Results</p><p>ESS score correlated with the disease duration, PD severity and the dosage of anti–parkinsonian drugs positively. PD patients using non–ergot and ergot dopamine agonist (DA) had higher ESS score than those without DA. There was no difference in ESS score between PD patients treated with non–ergot DA and ergot DA. PD patients with experience of sudden onset sleep had higher ESS score than those without it.</p><p>Conclusions</p><p>Not only non–ergot DA but also the other anti–Parkinsonian drugs cause sudden onset sleep and excessive daytime sleepiness. It is important to check the presence of sudden onset sleep regardless of any kind of anti–parkinsonian drugs. It was suggested that ESS score could become an important indicator of sudden onset sleep.</p>

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