Peak Work Rate during Exercise Could Detect Frailty Status in Elderly Patients with Stable Heart Failure
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- Kawashima Kazuhiro
- Department of Cardiology, National Center for Geriatrics and Gerontology
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- Hirashiki Akihiro
- Department of Cardiology, National Center for Geriatrics and Gerontology Department of Cardiology, Nagoya University Graduate School of Medicine
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- Nomoto Kenichiro
- Department of Cardiology, National Center for Geriatrics and Gerontology
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- Kokubo Manabu
- Department of Cardiology, National Center for Geriatrics and Gerontology
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- Shimizu Atsuya
- Department of Cardiology, National Center for Geriatrics and Gerontology
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- Sakurai Takashi
- Department of Cardiology, National Center for Geriatrics and Gerontology
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- Kondo Izumi
- Department of Cardiology, National Center for Geriatrics and Gerontology
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- Washimi Yukihiko
- Department of Cardiology, National Center for Geriatrics and Gerontology
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- Arai Hidenori
- Department of Cardiology, National Center for Geriatrics and Gerontology
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- Toba Kenji
- Department of Cardiology, National Center for Geriatrics and Gerontology
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- Murohara Toyoaki
- Department of Cardiology, Nagoya University Graduate School of Medicine
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抄録
<p>The Kihon Checklist (KCL) is a reliable tool for determining frailty status in the elderly. However, there is no information in the literature about the relationship between frailty status and exercise capacity. Here, we examined the associations between cardiopulmonary exercise testing parameters and frailty status in elderly patients with stable heart failure (HF).</p><p>Ninety-two elderly patients with stable HF were evaluated using cardiopulmonary exercise testing and the KCL. A KCL score of 0-3 was classified as robust, 4-7 as pre-frail, and ≥ 8 as frail.</p><p>Mean age, peak VO2, and KCL score were 81.7 years, 13.2 mL/kg/minute, and 10.7, respectively. KCL score was significantly correlated with peak VO2 (r = −0.527, P < 0.001) and peak work rate (r = −0.632, P < 0.001). In patients with frailty (n = 63), the peak work rate (WR) was significantly lower than it was in patients without frailty (n = 29; 39.9 versus 69.5 W, respectively; P < 0.001). Multivariate analysis revealed that peak WR and peak systolic blood pressure were significant, independent predictors of frailty (β = −0.108 and −0.045, respectively). In a diagnostic performance plot analysis, a cutoff value for peak WR of 51.9 W was the best predictor of frailty.</p><p>Frailty status was significantly associated with peak WR and peak systolic blood pressure in elderly patients with stable HF. Therefore, cardiopulmonary exercise testing may be useful for assessing frailty status in this patient population.</p>
収録刊行物
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- International Heart Journal
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International Heart Journal 60 (6), 1366-1372, 2019-11-30
一般社団法人 インターナショナル・ハート・ジャーナル刊行会
