The potential of G-quadruplexes as a therapeutic target for neurological diseases

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  • Shioda Norifumi
    Department of Genomic Neurology, Institute of Molecular Embryology and Genetics, Kumamoto University
  • Yabuki Yasushi
    Department of Genomic Neurology, Institute of Molecular Embryology and Genetics, Kumamoto University
  • Asamitsu Sefan
    Department of Genomic Neurology, Institute of Molecular Embryology and Genetics, Kumamoto University

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  • 新たな神経疾患治療ターゲット～グアニン四重鎖～
  • アラタ ナ シンケイ シッカン チリョウ ターゲット : グアニン ヨン ジュウサ

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Abstract

<p>The most common form of DNA is a right-handed helix, the B-form DNA. DNA can also adopt a variety of alternative conformations, termed non-B-form DNA secondary structures, including the G-quadruplex (G4). Furthermore, non-canonical RNA G4 secondary structures are also observed. Recent bioinformatics analysis revealed genomic positions of G4. In addition, G4 formation may be associated with various biological functions, including DNA replication, transcription, epigenetic modification, and RNA metabolism. In this review, we focus on G4 structures in neuronal functions, which may have important roles reveal mechanisms underlying neurological disorders. In addition, we discuss the potential of G4s as a therapeutic target for neurological diseases.</p>

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