Intracellular accumulation-independent cytotoxicity of pentavalent organoantimony compounds in cultured vascular endothelial cells
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- Hara Takato
- Faculty of Pharmaceutical Sciences, Toho University
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- Nakano Shihoko
- Faculty of Pharmaceutical Sciences, Tokyo University of Science
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- Kitamura Yuki
- School of Pharmaceutical Sciences, Aichi Gakuin University
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- Yamamoto Chika
- Faculty of Pharmaceutical Sciences, Toho University
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- Yasuike Shuji
- School of Pharmaceutical Sciences, Aichi Gakuin University
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- Kaji Toshiyuki
- Faculty of Pharmaceutical Sciences, Tokyo University of Science
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<p>As the field of utilization of organic-inorganic hybrid molecules expands, the toxicology of these compounds is becoming more important. We have shown previously that there is a strong correlation between cytotoxicity and intracellular accumulation detected as metal content, which is modulated by the substituents, of organic-inorganic hybrid molecules. In this study, we investigated the cytotoxicity of pentavalent organoantimony compounds with three phenyl groups on cultured vascular endothelial cells. The results indicated that the cytotoxicity of pentavalent organoantimony compounds was not correlated with the hydrophobicity and intracellular accumulation of these compounds. Therefore, we suggest that hydrophobicity and intracellular accumulation are not necessarily predictive of cytotoxicity in organic-inorganic hybrid molecules.</p>
収録刊行物
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- The Journal of Toxicological Sciences
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The Journal of Toxicological Sciences 44 (12), 845-848, 2019
一般社団法人 日本毒性学会
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詳細情報 詳細情報について
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- CRID
- 1390283659826345728
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- NII論文ID
- 130007759779
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- NII書誌ID
- AN00002808
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- ISSN
- 18803989
- 03881350
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- NDL書誌ID
- 030185917
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- PubMed
- 31813903
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可