-
- Oe Shinji
- Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan
-
- Honma Yuichi
- Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan
-
- Yabuki Kei
- Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Japan
-
- Morino Kahori
- Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan
-
- Kumamoto Keiichiro
- Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Japan
-
- Hayashi Tsuguru
- Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan
-
- Kusanaga Masashi
- Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan
-
- Ogino Noriyoshi
- Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan
-
- Minami Sota
- Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan
-
- Shibata Michihiko
- Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan
-
- Abe Shintaro
- Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan
-
- Harada Masaru
- Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan
この論文をさがす
抄録
<p>A 37-year-old Wilson disease patient treated with D-penicillamine visited our hospital for the evaluation of his liver function. Laboratory data showed a low serum copper level and ceruloplasmin. The ratio of urinary copper to urinary creatinine in a spot urinary analysis after 4 days' cessation of D-penicillamine was under 0.1. We concluded that the copper chelation was excessive and changed D-penicillamine to zinc acetate. However, his liver function test results did not normalize. We performed a liver biopsy and discovered a high copper content. The liver dysfunction was improved after resuming chelating therapy. Accurate measurement of the hepatic copper content via a biopsy is important for the adequate management of this disease. </p>
収録刊行物
-
- Internal Medicine
-
Internal Medicine 59 (1), 77-81, 2020-01-01
一般社団法人 日本内科学会
