Primary Intracranial Malignant Epidermoid with Multiple Metastases in Internal Organs: A Rare Autopsy Case
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- Kawabe Keita
- Department of Neurosurgery, Nagaoka Red Cross Hospital, Nagaoka, Niigata, Japan
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- Nakayama Yoko
- Department of Neurosurgery, Nagaoka Red Cross Hospital, Nagaoka, Niigata, Japan
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- Jimbo Yasushi
- Department of Neurosurgery, Nagaoka Red Cross Hospital, Nagaoka, Niigata, Japan
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- Usuda Hiroyuki
- Department of Pathology, Nagaoka Red Cross Hospital, Nagaoka, Niigata, Japan
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- Toyoshima Yasuko
- Department of Pathology, Brain Research Institute, University of Niigata, Niigata, Niigata, Japan
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- Kawaguchi Tadashi
- Department of Neurosurgery, Nagaoka Red Cross Hospital, Nagaoka, Niigata, Japan
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<p>Primary intracranial malignant epidermoids are rare, with most cases developing from a pre-existing benign epidermoid cyst. We report a case involving a rare autopsy finding of a primary intracranial malignant epidermoid in the brainstem with cerebellopontine angle (CPA) involvement. A 53-year-old woman with double vision was diagnosed with right abducens palsy. At her visit to our hospital 3 months after the onset of the first symptom, she presented left hypoglossal nerve paralysis and truncal ataxia in addition to right abducens palsy. Magnetic resonance imaging (MRI) revealed a mass lesion (2-cm long and 3-cm thick) in the left CPA that exhibited gadolinium enhancement. Moreover, gadolinium-enhanced magnetic resonance imaging (MRI) revealed abnormal multiple brainstem and supratentorial mass lesions with partial enhancement. Whole-body computed tomography failed to identify any possible primary lesion. Following a tentative diagnosis of an epidermoid cyst with an assumption that the tumor was highly aggressive, we performed subtotal surgical resection of the CPA tumor. Histological findings revealed a malignant epidermoid in the CPA lesion. Although the patient underwent radiation and chemotherapy after the surgical resection, she died of respiratory failure 10 months after the onset of symptoms. Herein, we report the rare clinical course and autopsy data, and discuss the characteristic features of this rare condition.</p>
収録刊行物
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- NMC Case Report Journal
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NMC Case Report Journal 7 (1), 29-34, 2020
一般社団法人 日本脳神経外科学会
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詳細情報 詳細情報について
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- CRID
- 1390002184860410368
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- NII論文ID
- 130007779727
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- ISSN
- 21884226
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
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- 使用不可