Screening of a library of traditional Chinese medicines to identify compounds and extracts which inhibit <i>Toxoplasma gondii</i> growth

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Author(s)

    • SAITO Harunobu
    • National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine
    • MURATA Yuho
    • National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine
    • NONAKA Motohiro
    • National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine
    • KATO Kentaro
    • National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine|Laboratory of Sustainable Animal Environment, Graduate School of Agricultural Science, Tohoku University

Abstract

<p><i>Toxoplasma gondii </i>can cause severe encephalitis in immunocompromised patients. Although pyrimethamine and sulphadiazine have been standard therapeutic agents for the treatment of acute toxoplasmosis, they have toxic side effects. Therefore, there is a need to identify new drugs that are less toxic. Some traditional Chinese medicines (TCMs) have shown good efficacy in controlling <i>T. gondii </i>replication in mouse models. Here, we screened a natural product library comprising TCMs with the aim of identifying compounds and extracts with anti-toxoplasmosis activities. We found several hit compounds and extracts that could be candidates for new drugs against <i>T. gondii</i> infection.</p>

Journal

  • Journal of Veterinary Medical Science

    Journal of Veterinary Medical Science, 2020

    JAPANESE SOCIETY OF VETERINARY SCIENCE

Codes

  • NII Article ID (NAID)
    130007779788
  • Text Lang
    ENG
  • ISSN
    0916-7250
  • Data Source
    J-STAGE 
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