Serum Pepsinogen Values in Japanese Junior High School Students With Reference to <i>Helicobacter Pylori</i> Infection
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- Okuda Masumi
- Department of Pediatrics, Aichi Medical University School of Medicine Department of General Medicine and Community Health Science, Hyogo College of Medicine
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- Lin Yingsong
- Department of Public Health, Aichi Medical University, School of Medicine
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- Mabe Katsuhiro
- Department of Cancer Preventive Medicine, Graduate School of Medicine, Hokkaido University
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- Kato Mototsugu
- Division of Endoscopy, Hokkaido University Hospital
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- Osaki Takako
- Department of Infectious Diseases, Kyorin University School of Medicine
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- Miyamoto Ryosuke
- Department of Pediatrics, Aichi Medical University School of Medicine
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- Okumura Akihisa
- Department of Pediatrics, Aichi Medical University School of Medicine
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- Kamiya Shigeru
- Department of Infectious Diseases, Kyorin University School of Medicine
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- Kikuchi Shogo
- Department of Public Health, Aichi Medical University, School of Medicine
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<p>Background: Distributions of serum pepsinogen (PG) values were assessed in Helicobacter pylori-infected and non-infected junior high school students (aged 12–15 years) in Japan.</p><p>Methods: All junior high school students (1,225 in total) in Sasayama city, who were basically healthy, were asked to provide urine and serum samples, which were used to measure urine and serum H. pylori antibodies using ELISA kits and PG values. The subjects, whose urine and serum antibodies were both positive, were considered H. pylori infected.</p><p>Results: Of the 187 subjects who provided urine and blood samples, 8 were infected, 4 had discrepant results, 4 had negative serum antibody titers no less than 3.0 U/ml, and 171 were non-infected. In the H. pylori non-infected subjects, the median PG I and PG II values and PG I to PG II ratio (PG I/II) were 40.8 ng/mL, 9.5 ng/mL, and 4.4, respectively, whereas in the infected subjects, these values were 55.4 ng/mL, 17.0 ng/mL, and 3.3, respectively (each P < 0.01). In the non-infected subjects, PG I and PG II were significantly higher in males than in females (P < 0.01).</p><p>Conclusions: The PG I and PG II values were higher, and the PG I/II was lower in H. pylori infected students than in non-infected students. In H. pylori non-infected students, males showed higher PG I and PG II values than females. The distributions of PG values in junior high school students differed from those in adults.</p>
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ｅｐｉｄｅｍｉｏｌｏｇｙ
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Ｊｏｕｒｎａｌ ｏｆ Ｅｐｉｄｅｍｉｏｌｏｇｙ 30 (1), 30-36, 2020-01-05
日本疫学会