Decline in Handgrip Strength From Midlife to Late-Life is Associated With Dementia in a Japanese Community: The Hisayama Study
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- Hatabe Yozo
- Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University
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- Shibata Mao
- Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University
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- Ohara Tomoyuki
- Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University
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- Oishi Emi
- Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
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- Yoshida Daigo
- Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University
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- Honda Takanori
- Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University
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- Hata Jun
- Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
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- Kanba Shigenobu
- Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University
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- Kitazono Takanari
- Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
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- Ninomiya Toshiharu
- Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University
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Abstract
<p>Background: The association between decline in handgrip strength from midlife to late life and dementia is unclear.</p><p>Methods: Japanese community-dwellers without dementia aged 60 to 79 years (ie, individuals in late life; mean age, 68 years) were followed for 24 years (1988–2012) (n = 1,055); 835 of them had participated in a health examination in 1973–1974 (mean age, 53 years), and these earlier data were used for the midlife analysis. Using a Cox proportional hazards model, we estimated the risk conferred by a decline in handgrip strength over a 15-year period (1973–74 to 1988) from midlife to late life on the development of total dementia, Alzheimer’s disease (AD), and vascular dementia (VaD) over the late-life follow-up period from 1988 to 2012.</p><p>Results: During the follow-up, 368 subjects experienced total dementia. The age- and sex-adjusted incidence of total dementia increased significantly with greater decline in handgrip strength (increased or unchanged handgrip strength [≥+0%] 25.1, mildly decreased [−14 to −1%] 28.4, and severely decreased [≤−15%] 38.9 per 1,000 person-years). A greater decline in handgrip strength was significantly associated with higher risk of total dementia after adjusting for potential confounding factors; subjects with severely decreased handgrip strength had 1.51-fold (95% confidence interval, 1.14–1.99, P < 0.01) increased risk of total dementia compared to those with increased or unchanged handgrip strength. Similar significant findings were observed for AD, but not for VaD.</p><p>Conclusions: Our findings suggest that a greater decline in handgrip strength from midlife to late life is an important indicator for late-life onset of dementia.</p>
Journal
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- Journal of Epidemiology
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Journal of Epidemiology 30 (1), 15-23, 2020-01-05
Japan Epidemiological Association