Hepatic blood flows in patients with cirrhosis due to alcohol consumption before and after endoscopic injection sclerotherapy for esophagogastric varices: Comparison with those in cirrhotic patients caused by hepatitis C virus infection

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  • Shigefuku Ryuta
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Takahashi Hideaki
    Division of Gastroenterology, St. Marianna University School of Medicine Yokohama-City Seibu Hospital
  • Nakano Hiroyasu
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Hattori Nobuhiro
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Ikeda Hiroki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Watanabe Tsunamasa
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Matsunaga Kotaro
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Matsumoto Nobuyuki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Okuse Chiaki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki Municipal Tama Hospital
  • Sase Shigeru
    Anzai Medical Company, Ltd
  • Itoh Fumio
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Suzuki Michihiro
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki Municipal Tama Hospital

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Other Title
  • アルコール性肝硬変における内視鏡的食道静脈瘤硬化療法前後の血行動態の変化―C型肝硬変との比較―
  • アルコールセイ カンコウヘン ニ オケル ナイシキョウテキ ショクドウ ジョウミャクリュウ コウカ リョウホウ ゼンゴ ノ ケッコウ ドウタイ ノ ヘンカ : Cガタ カンコウヘン ト ノ ヒカク

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Abstract

<p>Aim: Hemodynamic changes in hepatic blood flow after endoscopic injection sclerotherapy (EIS) compared to the baseline blood flow are to be elucidated in patients with cirrhosis both due to alcohol consumption and hepatitis C virus (HCV) infection. Thus, hepatic arterial tissue blood flow (HATBF) and portal venous tissue blood flow (PVTBF) were evaluated by xenon computed tomography (Xe-CT) in patients with cirrhosis receiving EIS for esophagogastric varices (EGV).</p><p>Methods: Subjects were 18 patients with alcoholic cirrhosis and 19 patients with of HCV-related cirrhosis receiving EIS for EGV. Xe-CT was performed before and after EIS procedures. Total hepatic TBF (THTBF), splenic blood flow and PVTBF/HATBF (P/A) ratio were calculated.</p><p>Results: PVTBF (ml/100 ml/min; mean±SD) before and after EIS procedures were 25.6±6.3 and 29.8±6.2, respectively, in patients with alcoholic cirrhosis, and 28.9±9.4 and 29.2±8.7, respectively, in patients with HCV-related cirrhosis; the values were increased significantly in the former patients (p=0.006), while were not altered in the latter patients. In contrast, HATBF, THTBF and P/A ratios were not changed after EIS procedures compared to baseline values.</p><p>Conclusions: Portal venous flows were increased especially in patients with alcoholic cirrhosis after EIS procedures compared to those at baseline, and abstinence after admission might contribute to such hemodynamic changes.</p>

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