DNA damage induced by ultrasound and its cellular response

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  • FURUSAWA Yukihiro
    Department of Biology, Toyama Prefectural University
  • KUDO Nobuki
    Faculty of Information Science and Technology, Hokkaido University
  • KONDO Takashi
    Department of Radiology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama

Bibliographic Information

Other Title
  • 超音波によるDNA損傷と細胞応答

Abstract

<p>Recently, we reported on the occurrence of DNA double-strand breaks in different human cell lines exposed to ultrasound in vitro with some insight into the subsequent DNA damage response and repair pathways. The impact of these observed effects again sways between extremes. It could be advantageous if employed in gene therapy, wound and bone fracture-accelerated healing to promote cell proliferation, or in cancer eradication if the DNA lesions would culminate in cell death. Here, an overview of the rationale for therapeutic ultrasound and the salient knowledge on ultrasound-induced effects on the nucleus and genomic DNA is presented. The implications of the findings are discussed, hopefully to provide guidance to future ultrasound research.</p>

Journal

  • Choonpa Igaku

    Choonpa Igaku 47 (1), 3-13, 2019

    The Japan Society of Ultrasonics in Medicine

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