Anti inflammatory effects of cyclooxygenase inhibitor on human temporomandibular joint synoviocyte stimilated with interleukin-1<i>β</i> by microarray analysis.

DOI
  • MUTSUMI KAWASHIMA
    Department of Maxillofacial Surgery, Nihon University School of Dentistry at Matsudo
  • NAOMI OGURA
    Department of Maxillofacial Surgery, Nihon University School of Dentistry at Matsudo Research Institute of Oral Science, Nihon University School of Dentistry at Matsudo
  • YANO TERUO
    Department of Maxillofacial Surgery, Nihon University School of Dentistry at Matsudo
  • ISHIGAMI DAISUKE
    Department of Maxillofacial Surgery, Nihon University School of Dentistry at Matsudo
  • WATANABE SUGURU
    Department of Maxillofacial Surgery, Nihon University School of Dentistry at Matsudo
  • HATTORI TOSHIO
    Department of Maxillofacial Surgery, Nihon University School of Dentistry at Matsudo
  • FUKUZATO HIDEHIKO
    Department of Maxillofacial Surgery, Nihon University School of Dentistry at Matsudo
  • ITO KO
    Department of Maxillofacial Surgery, Nihon University School of Dentistry at Matsudo Research Institute of Oral Science, Nihon University School of Dentistry at Matsudo
  • KONDOH TOSHIROU
    Department of Maxillofacial Surgery, Nihon University School of Dentistry at Matsudo Research Institute of Oral Science, Nihon University School of Dentistry at Matsudo

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  • 遺伝子発現プロファイリングを用いたIL-1<i>β</i>刺激顎関節滑膜細胞に対するCOX阻害薬の抗炎症効果の解析

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Abstract

<p>BACKGROUND：Non-steroidal anti-inflammatory drugs (NSAIDs) have been widely used for the management of pain and inflammation. However, little remains known about the effects of NSAIDs on synovitis of the human temporomandibular joint (TMJ).</p><p>Cyclooxygenase (COX) inhibitor are one of main NSAIDs. This study investigate the effects of COX inhibitor on fibroblast-like synoviocytes (FLS) derived from the human TMJ.</p><p>METHODS：Human synovial tissue was obtained from a patient with internal derangement who underwent arthroscopy of the TMJ. FLSs were prepared from the tissues using the outgrowth method. A COX inhibitor (indometacin or celecoxib) was added to the IL-1β stimulating cells in culture. Gene expression profiling was performed using microarray analysis.</p><p>RESULTS：The expressions of IL-23A, IL-11, and IL-33, which were up-regulated in FLSs stimulated by IL-1xxxwere down-regulated in the cells treated by COX inhibitors.</p><p>CONCLUSION：COX inhibitors such as indomethacin and celecoxib reduce the gene expression of inflammatory cytokines induced by IL-1β Our results suggest that these COX inhibitors are useful for treating synovitis in TMJ.</p>

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