Characterization of low adherence population in asthma patients from Japan using Adherence Starts with Knowledge-12

• Kimura Yuka

  Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences

• Koya Toshiyuki

  Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences

• Hasegawa Takashi

  Department of General Medicine, Niigata University Medical and Dental Hospital

• Ueno Hiroshi

  Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences

• Yoshizawa Kazutaka

  Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences

• Kimura Yosuke

  Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences

• Hayashi Masachika

  Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences

• Watanabe Satoshi

  Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences

• Kikuchi Toshiaki

  Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences

• the Niigata Asthma Treatment Study Group

抄録

Background: Adherence Starts with Knowledge-12 (ASK-12) is a useful indicator of drug adherence. In this study, we analyzed patient background including social and psychological factors in a low-adherence group of patients with asthma defined using ASK-12. Methods: From a questionnaire survey for patients with asthma from the Niigata Prefecture, Japan, conducted in the fall of 2016, we enrolled patients who answered all ASK-12 items and underwent a measured respiratory function test within 1 year. The low-adherence group (ASK-12 ≥ 28) was compared with the control group (ASK-12 < 28), and we conducted a cluster analysis of the low-adherence group. Results: There were 170 patients in the low-adherence group and 402 patients in the control group. There was a significant difference between age, gender, working status, smoking history, the percentage of forced expiratory volume in one second (%FEV₁), asthma control test (ACT), and Patient Health Questionnaire-9 (PHQ-9) score between the two groups. Logistic analysis revealed that working status (working), % FEV₁ (<90%), and PHQ-9 score (>5) were independent factors for the low-adherence group. The cluster analysis identified three clusters in the low-adherence group. Among these, one cluster was characterized by elderly males with chronic obstructive pulmonary disease and another by middle-aged nonsmoking females with a depression tendency, had problems with asthma control. Conclusions: Several factors were considered to be attributed to low drug-adherence. There were several phenotypes in the low-adherence population correlated with incomplete asthma control. Intervention with drug adherence should be a future goal for asthma treatment.

収録刊行物

• Allergology International

  Allergology International 69 (1), 61-65, 2020

  一般社団法人日本アレルギー学会

キーワード

• Bronchial asthma
• Adherence starts with Knowledge-12 (ASK-12)
• Questionnaire survey
• Depression status
• Working status

詳細情報

• CRID: 1390565134819073664
• NII論文ID: 130007788673
• DOI: 10.1016/j.alit.2019.07.006
• ISSN: 14401592
• ISSN: 13238930
• Web Site: https://api.elsevier.com/content/article/PII:S1323893019301078?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S1323893019301078?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2020301974
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
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