Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids

• YAMAMURA Ryodai

  Graduate School of Medicine, Hokkaido University, N15, W7, Kita-ku, Sapporo 060-8638, Japan

• NAKAMURA Koshi

  Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan Faculty of Medicine, Hokkaido University, N15, W7, Kita-ku, Sapporo 060-8638, Japan

• KITADA Naoya

  Graduate School of Life Science, Hokkaido University, N10, W8, Kita-ku, Sapporo 060-0810, Japan

• AIZAWA Tomoyasu

  Faculty of Advanced Life Science, Hokkaido University, N10, W8, Kita-ku, Sapporo 060-0810, Japan

• SHIMIZU Yu

  Graduate School of Life Science, Hokkaido University, N10, W8, Kita-ku, Sapporo 060-0810, Japan

• NAKAMURA Kiminori

  Faculty of Advanced Life Science, Hokkaido University, N10, W8, Kita-ku, Sapporo 060-0810, Japan

• AYABE Tokiyoshi

  Faculty of Advanced Life Science, Hokkaido University, N10, W8, Kita-ku, Sapporo 060-0810, Japan

• KIMURA Takashi

  Faculty of Medicine, Hokkaido University, N15, W7, Kita-ku, Sapporo 060-8638, Japan

• TAMAKOSHI Akiko

  Faculty of Medicine, Hokkaido University, N15, W7, Kita-ku, Sapporo 060-8638, Japan

抄録

In recent years, short-chain fatty acids (SCFAs) have been reported to play an important role in maintaining human health. Fecal SCFA concentrations correlate well with colonic SCFA status and gut microbiota composition. However, the associations with the gut microbiota functional pathway, dietary intake, blood SCFAs, and fecal SCFAs remain uncertain. To clarify these relationships, we collected fecal samples, blood samples, and dietary habit data from 12 healthy adults aged 22–51 years. The relative abundance of several SCFA-producing bacteria, gut microbiota diversity, and functional pathways related to SCFA biosynthesis were positively associated with fecal SCFAs even after adjusting for age and sex. Furthermore, fecal acetate was likely to be positively associated with serum acetate. By contrast, dietary intake was not associated with fecal SCFAs. Overall, the present study highlights the potential usefulness of fecal SCFAs as an indicator of the gut microbiota ecosystem and dynamics of SCFAs in the human body.

収録刊行物

• Bioscience of Microbiota, Food and Health

  Bioscience of Microbiota, Food and Health 39 (1), 11-17, 2020

  BMFH出版会

キーワード

• gut microbiota
• fecal short-chain fatty acids
• serum short-chain fatty acids
• dietary intake
• human

詳細情報

• CRID: 1390565134820104320
• NII論文ID: 130007788976
• DOI: 10.12938/bmfh.19-010
• ISSN: 21863342
• Web Site: https://www.jstage.jst.go.jp/article/bmfh/39/1/39_19-010/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2020342190
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
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